HNRNPR

Heterogeneous nuclear ribonucleoprotein R
PDB rendering based on 2dk2.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 2DK2​
Identifiers
Symbols	HNRNPR ; HNRPR; hnRNP-R
External IDs	OMIM: 607201 MGI: 1891692 HomoloGene: 4251 GeneCards: HNRNPR Gene
Gene ontology Molecular function • nucleotide binding • RNA binding • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • spliceosomal complex • nucleolus • cytoplasm • ribonucleoprotein complex • catalytic step 2 spliceosome Biological process • mRNA splicing, via spliceosome • mRNA processing • RNA splicing • gene expression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	10236	74326
Ensembl	ENSG00000125944	ENSMUSG00000066037
UniProt	O43390	A2AW40
RefSeq (mRNA)	NM_001102397	NM_001277121
RefSeq (protein)	NP_001095867	NP_001264050
Location (UCSC)	Chr 1: 23.3 – 23.34 Mb	Chr 4: 136.31 – 136.36 Mb
PubMed search

Heterogeneous nuclear ribonucleoprotein R is a protein that in humans is encoded by the HNRNPR gene.^[1][2]

Function

This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has three repeats of quasi-RRM domains that bind to RNAs and also contains a nuclear localization motif.^[2]

Interactions

HNRNPR has been shown to interact with SMN1^[3][4] and PRMT1.^[5][6]

References

1. Hassfeld W, Chan EK, Mathison DA, Portman D, Dreyfuss G, Steiner G, Tan EM (Jan 1998). "Molecular definition of heterogeneous nuclear ribonucleoprotein R (hnRNP R) using autoimmune antibody: immunological relationship with hnRNP P". Nucleic Acids Research 26 (2): 439–45. doi:10.1093/nar/26.2.439. PMC 147279. PMID 9421497.
2. "Entrez Gene: HNRPR heterogeneous nuclear ribonucleoprotein R".
3. Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G (Oct 2001). "SMN interacts with a novel family of hnRNP and spliceosomal proteins". The EMBO Journal 20 (19): 5443–52. doi:10.1093/emboj/20.19.5443. PMC 125643. PMID 11574476.
4. Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M (Jan 2002). "Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?". Human Molecular Genetics 11 (1): 93–105. doi:10.1093/hmg/11.1.93. PMID 11773003.
5. Wada K, Inoue K, Hagiwara M (Aug 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy". Biochimica et Biophysica Acta 1591 (1-3): 1–10. doi:10.1016/S0167-4889(02)00202-1. PMID 12183049.
6. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (Sep 2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.

Further reading

• Mourelatos Z, Abel L, Yong J, Kataoka N, Dreyfuss G (Oct 2001). "SMN interacts with a novel family of hnRNP and spliceosomal proteins". The EMBO Journal 20 (19): 5443–52. doi:10.1093/emboj/20.19.5443. PMC 125643. PMID 11574476.
• Rossoll W, Kröning AK, Ohndorf UM, Steegborn C, Jablonka S, Sendtner M (Jan 2002). "Specific interaction of Smn, the spinal muscular atrophy determining gene product, with hnRNP-R and gry-rbp/hnRNP-Q: a role for Smn in RNA processing in motor axons?". Human Molecular Genetics 11 (1): 93–105. doi:10.1093/hmg/11.1.93. PMID 11773003.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (Apr 2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Wada K, Inoue K, Hagiwara M (Aug 2002). "Identification of methylated proteins by protein arginine N-methyltransferase 1, PRMT1, with a new expression cloning strategy". Biochimica et Biophysica Acta 1591 (1-3): 1–10. doi:10.1016/S0167-4889(02)00202-1. PMID 12183049.
• Angenstein F, Evans AM, Settlage RE, Moran ST, Ling SC, Klintsova AY, Shabanowitz J, Hunt DF, Greenough WT (Oct 2002). "A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons". The Journal of Neuroscience 22 (20): 8827–37. PMID 12388589.
• Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S (May 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (Jan 2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Huang J, Chen XH, Wu K, Xu P (May 2005). "Cloning and expression of a novel isoform of heterogeneous nuclear ribonucleoprotein-R". NeuroReport 16 (7): 727–30. doi:10.1097/00001756-200505120-00014. PMID 15858414.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Szafranski K, Schindler S, Taudien S, Hiller M, Huse K, Jahn N, Schreiber S, Backofen R, Platzer M (2007). "Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns". Genome Biology 8 (8): R154. doi:10.1186/gb-2007-8-8-r154. PMC 2374985. PMID 17672918.

External links

• HNRNPR human gene location in the UCSC Genome Browser.
• HNRNPR human gene details in the UCSC Genome Browser.