Small nuclear ribonucleoprotein polypeptide E

Small nuclear ribonucleoprotein polypeptide E
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CW1​, 3PGW​, 3S6N​, 4F7U​, 4PJO​, 4V98​, 4WZJ​
Identifiers
Symbols	SNRPE ; B-raf; HYPT11; SME; Sm-E
External IDs	OMIM: 128260 MGI: 98346 HomoloGene: 37729 GeneCards: SNRPE Gene
Gene ontology Molecular function • RNA binding • protein binding Cellular component • nucleus • nucleoplasm • spliceosomal complex • U5 snRNP • U7 snRNP • U1 snRNP • U2 snRNP • U4 snRNP • U12-type spliceosomal complex • cytosol • small nuclear ribonucleoprotein complex • methylosome • pICln-Sm protein complex • SMN-Sm protein complex • U4/U6 x U5 tri-snRNP complex • extracellular exosome • precatalytic spliceosome • catalytic step 2 spliceosome Biological process • spliceosomal complex assembly • spliceosomal snRNP assembly • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • histone mRNA metabolic process • RNA splicing • gene expression • mRNA 3'-end processing • ncRNA metabolic process • hair cycle Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6635	20643
Ensembl	ENSG00000182004	ENSMUSG00000090553
UniProt	P62304	P62305
RefSeq (mRNA)	NM_001304464	NM_009227
RefSeq (protein)	NP_001291393	NP_033253
Location (UCSC)	Chr 1: 203.86 – 203.87 Mb	Chr 1: 133.6 – 133.61 Mb
PubMed search

Small nuclear ribonucleoprotein E is a protein that in humans is encoded by the SNRPE gene.^[1][2][3]

Interactions

Small nuclear ribonucleoprotein polypeptide E has been shown to interact with DDX20^[4] and Small nuclear ribonucleoprotein polypeptide F.^[5]

References

1. Fautsch MP, Wieben ED (January 1992). "Transcriptional regulation of the small nuclear ribonucleoprotein E protein gene. Identification of cis-acting sequences with homology to genes encoding ribosomal proteins". J Biol Chem 266 (34): 23288–95. PMID 1835977.
2. Neiswanger K, Stanford DR, Sparkes RS, Nishimura D, Mohandas T, Klisak I, Heinzmann C, Wieben ED (September 1990). "Assignment of the gene for the small nuclear ribonucleoprotein E (SNRPE) to human chromosome 1q25-q43". Genomics 7 (4): 503–8. doi:10.1016/0888-7543(90)90192-W. PMID 2143747.
3. "Entrez Gene: SNRPE small nuclear ribonucleoprotein polypeptide E".
4. Charroux, B; Pellizzoni L; Perkinson R A; Shevchenko A; Mann M; Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333.
5. Fury, M G; Zhang W; Christodoulopoulos I; Zieve G W (November 1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. (UNITED STATES) 237 (1): 63–9. doi:10.1006/excr.1997.3750. ISSN 0014-4827. PMID 9417867.

Further reading

• Sauterer RA, Goyal A, Zieve GW (1990). "Cytoplasmic assembly of small nuclear ribonucleoprotein particles from 6 S and 20 S RNA-free intermediates in L929 mouse fibroblasts.". J. Biol. Chem. 265 (2): 1048–58. PMID 1688550.
• Stanford DR, Rohleder A, Neiswanger K, Wieben ED (1987). "DNA sequence of a human Sm autoimmune antigen. The multigene family contains a processed pseudogene.". J. Biol. Chem. 262 (21): 9931–4. PMID 2440864.
• Feeney RJ, Sauterer RA, Feeney JL, Zieve GW (1989). "Cytoplasmic assembly and nuclear accumulation of mature small nuclear ribonucleoprotein particles.". J. Biol. Chem. 264 (10): 5776–83. PMID 2522439.
• Stanford DR, Perry CA, Holicky EL, et al. (1988). "The small nuclear ribonucleoprotein E protein gene contains four introns and has upstream similarities to genes for ribosomal proteins.". J. Biol. Chem. 263 (33): 17772–9. PMID 2972723.
• Stanford DR, Kehl M, Perry CA, et al. (1989). "The complete primary structure of the human snRNP E protein.". Nucleic Acids Res. 16 (22): 10593–605. doi:10.1093/nar/16.22.10593. PMC 338926. PMID 2974536.
• Woppmann A, Rinke J, Lührmann R (1989). "Direct cross-linking of snRNP proteins F and 70K to snRNAs by ultra-violet radiation in situ.". Nucleic Acids Res. 16 (23): 10985–1004. doi:10.1093/nar/16.23.10985. PMC 338992. PMID 2974540.
• Kamiyama T, Aoki N, Yuasa Y (1993). "B-raf oncogene: activation by rearrangements and assignment to human chromosome 7.". Jpn. J. Cancer Res. 84 (3): 250–6. doi:10.1111/j.1349-7006.1993.tb02864.x. PMID 8098025.
• Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core.". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
• Liu Q, Fischer U, Wang F, Dreyfuss G (1997). "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.". Cell 90 (6): 1013–21. doi:10.1016/S0092-8674(00)80367-0. PMID 9323129.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1998). "Multiple protein: protein interactions between the snRNP common core proteins.". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Kambach C, Walke S, Young R, et al. (1999). "Crystal structures of two Sm protein complexes and their implications for the assembly of the spliceosomal snRNPs.". Cell 96 (3): 375–87. doi:10.1016/S0092-8674(00)80550-4. PMID 10025403.
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems.". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, et al. (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli.". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure.". EMBO J. 20 (1–2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
• Gubitz AK, Mourelatos Z, Abel L, et al. (2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. 277 (7): 5631–6. doi:10.1074/jbc.M109448200. PMID 11714716.
• Pellizzoni L, Baccon J, Rappsilber J, et al. (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Friesen WJ, Wyce A, Paushkin S, et al. (2002). "A novel WD repeat protein component of the methylosome binds Sm proteins". J. Biol. Chem. 277 (10): 8243–7. doi:10.1074/jbc.M109984200. PMID 11756452.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.