SNRPG

Small nuclear ribonucleoprotein polypeptide G
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 3CW1​, 3PGW​, 3S6N​, 4F7U​, 4PJO​, 4V98​, 4WZJ​
Identifiers
Symbols	SNRPG ; SMG; Sm-G
External IDs	OMIM: 603542 MGI: 1915261 HomoloGene: 37730 GeneCards: SNRPG Gene
Gene ontology Molecular function • protein binding • poly(A) RNA binding Cellular component • nucleoplasm • spliceosomal complex • U7 snRNP • U1 snRNP • U4 snRNP • U12-type spliceosomal complex • small nucleolar ribonucleoprotein complex • cytosol • small nuclear ribonucleoprotein complex • methylosome • SMN-Sm protein complex • catalytic step 2 spliceosome Biological process • spliceosomal complex assembly • spliceosomal snRNP assembly • mRNA splicing, via spliceosome • transcription from RNA polymerase II promoter • termination of RNA polymerase II transcription • histone mRNA metabolic process • RNA splicing • gene expression • mRNA 3'-end processing • ncRNA metabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6637	68011
Ensembl	ENSG00000143977	ENSMUSG00000049124
UniProt	P62308	P62309
RefSeq (mRNA)	NM_003096	NM_026506
RefSeq (protein)	NP_003087	NP_080782
Location (UCSC)	Chr 2: 70.28 – 70.29 Mb	Chr 17: 26.1 – 26.1 Mb
PubMed search

Small nuclear ribonucleoprotein G is a protein that in humans is encoded by the SNRPG gene.^[1][2]

Interactions

SNRPG has been shown to interact with DDX20^[3] and TACC1.^[4]

References

1. Hermann H, Fabrizio P, Raker VA, Foulaki K, Hornig H, Brahms H, Lührmann R (June 1995). "snRNP Sm proteins share two evolutionarily conserved sequence motifs which are involved in Sm protein-protein interactions". EMBO J. 14 (9): 2076–88. PMC 398308. PMID 7744013.
2. "Entrez Gene: SNRPG small nuclear ribonucleoprotein polypeptide G".
3. Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (December 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
4. Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (August 2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.

Further reading

• Heinrichs V, Hackl W, Lührmann R (1992). "Direct binding of small nuclear ribonucleoprotein G to the Sm site of small nuclear RNA. Ultraviolet light cross-linking of protein G to the AAU stretch within the Sm site (AAUUUGUGG) of U1 small nuclear ribonucleoprotein reconstituted in vitro". J. Mol. Biol. 227 (1): 15–28. doi:10.1016/0022-2836(92)90678-D. PMID 1387914.
• Plessel G, Lührmann R, Kastner B (1997). "Electron microscopy of assembly intermediates of the snRNP core: morphological similarities between the RNA-free (E.F.G) protein heteromer and the intact snRNP core". J. Mol. Biol. 265 (2): 87–94. doi:10.1006/jmbi.1996.0713. PMID 9020971.
• Fury MG, Zhang W, Christodoulopoulos I, Zieve GW (1997). "Multiple protein: protein interactions between the snRNP common core proteins". Exp. Cell Res. 237 (1): 63–9. doi:10.1006/excr.1997.3750. PMID 9417867.
• Bühler D, Raker V, Lührmann R, Fischer U (1999). "Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy". Hum. Mol. Genet. 8 (13): 2351–7. doi:10.1093/hmg/8.13.2351. PMID 10556282.
• Charroux B, Pellizzoni L, Perkinson RA, Shevchenko A, Mann M, Dreyfuss G (1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. PMC 2168095. PMID 10601333.
• Charroux B, Pellizzoni L, Perkinson RA, Yong J, Shevchenko A, Mann M, Dreyfuss G (2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. PMC 2174312. PMID 10725331.
• Urlaub H, Raker VA, Kostka S, Lührmann R (2001). "Sm protein-Sm site RNA interactions within the inner ring of the spliceosomal snRNP core structure". EMBO J. 20 (1-2): 187–96. doi:10.1093/emboj/20.1.187. PMC 140196. PMID 11226169.
• Pellizzoni L, Baccon J, Rappsilber J, Mann M, Dreyfuss G (2002). "Purification of native survival of motor neurons complexes and identification of Gemin6 as a novel component". J. Biol. Chem. 277 (9): 7540–5. doi:10.1074/jbc.M110141200. PMID 11748230.
• Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Conte N, Charafe-Jauffret E, Delaval B, Adélaïde J, Ginestier C, Geneix J, Isnardon D, Jacquemier J, Birnbaum D (2002). "Carcinogenesis and translational controls: TACC1 is down-regulated in human cancers and associates with mRNA regulators". Oncogene 21 (36): 5619–30. doi:10.1038/sj.onc.1205658. PMID 12165861.
• Conte N, Delaval B, Ginestier C, Ferrand A, Isnardon D, Larroque C, Prigent C, Séraphin B, Jacquemier J, Birnbaum D (2003). "TACC1-chTOG-Aurora A protein complex in breast cancer". Oncogene 22 (50): 8102–16. doi:10.1038/sj.onc.1206972. PMID 14603251.
• Will CL, Schneider C, Hossbach M, Urlaub H, Rauhut R, Elbashir S, Tuschl T, Lührmann R (2004). "The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome". RNA 10 (6): 929–41. doi:10.1261/rna.7320604. PMC 1370585. PMID 15146077.
• Ma Y, Dostie J, Dreyfuss G, Van Duyne GD (2005). "The Gemin6-Gemin7 heterodimer from the survival of motor neurons complex has an Sm protein-like structure". Structure 13 (6): 883–92. doi:10.1016/j.str.2005.03.014. PMID 15939020.
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
• Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.