SNRPA1

Small nuclear ribonucleoprotein polypeptide A'
PDB rendering based on 1a9n.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1A9N​
Identifiers
Symbols	SNRPA1 ; Lea1
External IDs	OMIM: 603521 MGI: 1916231 HomoloGene: 2325 GeneCards: SNRPA1 Gene
Gene ontology Molecular function • protein binding • U2 snRNA binding • poly(A) RNA binding Cellular component • nucleoplasm • spliceosomal complex • U2 snRNP • small nuclear ribonucleoprotein complex • catalytic step 2 spliceosome Biological process • mRNA splicing, via spliceosome • RNA splicing • gene expression Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6627	68981
Ensembl	ENSG00000131876	ENSMUSG00000030512
UniProt	P09661	P57784
RefSeq (mRNA)	NM_003090	NM_021336
RefSeq (protein)	NP_003081	NP_067311
Location (UCSC)	Chr 15: 101.28 – 101.3 Mb	Chr 7: 66.06 – 66.07 Mb
PubMed search

U2 small nuclear ribonucleoprotein A' is a protein that in humans is encoded by the SNRPA1 gene.^[1][2]

Interactions

SNRPA1 has been shown to interact with CDC5L.^[3]

References

1. Sillekens PT, Beijer RP, Habets WJ, van Verooij WJ (May 1989). "Molecular cloning of the cDNA for the human U2 snRNA-specific A' protein". Nucleic Acids Res 17 (5): 1893–906. doi:10.1093/nar/17.5.1893. PMC 317531. PMID 2928112.
2. "Entrez Gene: SNRPA1 small nuclear ribonucleoprotein polypeptide A'".
3. Ajuh, P; Kuster B; Panov K; Zomerdijk J C; Mann M; Lamond A I (December 2000). "Functional analysis of the human CDC5L complex and identification of its components by mass spectrometry". EMBO J. (ENGLAND) 19 (23): 6569–81. doi:10.1093/emboj/19.23.6569. ISSN 0261-4189. PMC 305846. PMID 11101529.

Further reading

• Ohno M, Kataoka N, Shimura Y (1991). "A nuclear cap binding protein from HeLa cells.". Nucleic Acids Res. 18 (23): 6989–95. doi:10.1093/nar/18.23.6989. PMC 332760. PMID 2148205.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Kjems J, Sharp PA (1993). "The basic domain of Rev from human immunodeficiency virus type 1 specifically blocks the entry of U4/U6.U5 small nuclear ribonucleoprotein in spliceosome assembly". J. Virol. 67 (8): 4769–76. PMC 237863. PMID 8331728.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Blencowe BJ, Issner R, Nickerson JA, Sharp PA (1998). "A coactivator of pre-mRNA splicing". Genes Dev. 12 (7): 996–1009. doi:10.1101/gad.12.7.996. PMC 316672. PMID 9531537.
• Price SR, Evans PR, Nagai K (1998). "Crystal structure of the spliceosomal U2B"-U2A' protein complex bound to a fragment of U2 small nuclear RNA". Nature 394 (6694): 645–50. doi:10.1038/29234. PMID 9716128.
• Neubauer G, King A, Rappsilber J, et al. (1998). "Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex". Nat. Genet. 20 (1): 46–50. doi:10.1038/1700. PMID 9731529.
• Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). "The SRm160/300 splicing coactivator is required for exon-enhancer function". Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125–30. doi:10.1073/pnas.96.11.6125. PMC 26846. PMID 10339552.
• Lundin M, Mikkelsen B, Gudim M, Syed M (2000). "Gene Structure of the U2 snRNP-Specific A' Protein Gene from Salmo salar: Alternative Transcripts Observed". Marine biotechnology 2 (2): 204–211. doi:10.1007/s101269900015. PMID 10811961.
• Fong YW, Zhou Q (2002). "Stimulatory effect of splicing factors on transcriptional elongation". Nature 414 (6866): 929–33. doi:10.1038/414929a. PMID 11780068.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298.
• Jurica MS, Licklider LJ, Gygi SR, et al. (2002). "Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis". RNA 8 (4): 426–39. doi:10.1017/S1355838202021088. PMC 1370266. PMID 11991638.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.