Halimadienyl-diphosphate synthase

Halimadienyl-diphosphate synthase (EC 5.5.1.16, Rv3377c, halimadienyl diphosphate synthase, tuberculosinol diphosphate synthase, halima-5(6),13-dien-15-yl-diphosphate lyase (cyclizing)) is an enzyme with systematic name halima-5,13-dien-15-yl-diphosphate lyase (decyclizing).^[1] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate

\rightleftharpoons

tuberculosinyl diphosphate

This enzyme requires Mg²⁺ for activity.

References

↑ Nakano, C., Okamura, T., Sato, T., Dairi, T. and Hoshino, T. (2005). "Mycobacterium tuberculosis H37Rv3377c encodes the diterpene cyclase for producing the halimane skeleton". Chem. Commun. (Camb.) (8): 1016–1018. doi:10.1039/b415346d. PMID 15719101.

External links

Halimadienyl-diphosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerase: Intramolecular Lyases (EC 5.5)

5.5.1 Intramolecular Lyases

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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