Prosolanapyrone-III cycloisomerase

Prosolanapyrone-III cycloisomerase (EC 5.5.1.20, Sol5, SPS, solanapyrone synthase (bifunctional enzyme: prosolanapyrone II oxidase/prosolanapyrone III cyclosiomerase)) is an enzyme with systematic name prosolanapyrone-III:(-)-solanapyrone A isomerase.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

prosolanapyrone III

\rightleftharpoons

(-)-solanapyrone A

The enzyme is involved in the biosynthesis of the phytotoxin solanapyrone in some fungi.

References

↑ Kasahara, K., Miyamoto, T., Fujimoto, T., Oguri, H., Tokiwano, T., Oikawa, H., Ebizuka, Y. and Fujii, I. (2010). "Solanapyrone synthase, a possible Diels-Alderase and iterative type I polyketide synthase encoded in a biosynthetic gene cluster from Alternaria solani". Chembiochem. 11: 1245–1252. doi:10.1002/cbic.201000173. PMID 20486243.
↑ Katayama, K., Kobayashi, T., Oikawa, H., Honma, M. and Ichihara, A. (1998). "Enzymatic activity and partial purification of solanapyrone synthase: first enzyme catalyzing Diels-Alder reaction". Biochim. Biophys. Acta 1384 (2): 387–395. doi:10.1016/s0167-4838(98)00040-5. PMID 9659400.
↑ Katayama, K., Kobayashi, T., Chijimatsu, M., Ichihara, A. and Oikawa, H. (2008). "Purification and N-terminal amino acid sequence of solanapyrone synthase, a natural Diels-Alderase from Alternaria solani". Biosci. Biotechnol. Biochem. 72 (2): 604–607. doi:10.1271/bbb.70600. PMID 18256508.

External links

Prosolanapyrone-III cycloisomerase at the US National Library of Medicine Medical Subject Headings (MeSH)

Isomerase: Intramolecular Lyases (EC 5.5)

5.5.1 Intramolecular Lyases

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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