Terpentedienyl-diphosphate synthase

Terpentedienyl-diphosphate synthase
Identifiers
EC number	5.5.1.15
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Terpentedienyl-diphosphate synthase (EC 5.5.1.15, terpentedienol diphosphate synthase, Cyc1, clerodadienyl diphosphate synthase) is an enzyme with systematic name terpentedienyl-diphosphate lyase (decyclizing).^[1][2][3] This enzyme catalyses the following chemical reaction

geranylgeranyl diphosphate $\rightleftharpoons$ terpentedienyl diphosphate

This enzyme requires Mg²⁺.

References

1. Dairi, T., Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K. and Seto, H. (2001). "Eubacterial diterpene cyclase genes essential for production of the isoprenoid antibiotic terpentecin". J. Bacteriol. 183: 6085–6094. doi:10.1128/jb.183.20.6085-6094.2001. PMID 11567009.
2. Hamano, Y., Kuzuyama, T., Itoh, N., Furihata, K., Seto, H. and Dairi, T. (2002). "Functional analysis of eubacterial diterpene cyclases responsible for biosynthesis of a diterpene antibiotic, terpentecin". J. Biol. Chem. 277: 37098–37104. doi:10.1074/jbc.m206382200. PMID 12138123.
3. Eguchi, T., Dekishima, Y., Hamano, Y., Dairi, T., Seto, H. and Kakinuma, K. (2003). "A new approach for the investigation of isoprenoid biosynthesis featuring pathway switching, deuterium hyperlabeling, and ¹H NMR spectroscopy. The reaction mechanism of a novel streptomyces diterpene cyclase". J. Org. Chem. 68: 5433–5438. doi:10.1021/jo026728a. PMID 12839434.

External links

• Terpentedienyl-diphosphate synthase at the US National Library of Medicine Medical Subject Headings (MeSH)