Helper-component proteinase

Helper-component proteinase

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metabolic pathway

PDB structures

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Helper-component proteinase (EC 3.4.22.45, HC-Pro) is an enzyme.^[1]^[2] This enzyme catalyses the following chemical reaction

Hydrolyses a Gly-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-Gly, in the processing of the potyviral polyprotein

This enzyme is present in many potyviruses.

References

↑ Kasschau, K.D. and Carrington, J.C. (1995). "Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus". Virology 209: 268–273. doi:10.1006/viro.1995.1254. PMID 7747479.
↑ Verchot, J. (1998). "Potyvirus helper component proteinase". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Handbook of Proteolytic Enzymes. pp. 677–679.

External links

Helper-component proteinase at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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