Histolysain

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Histolysain (EC 3.4.22.35, histolysin, Entamoeba histolytica cysteine proteinase, amebapain, Entamoeba histolytica cysteine protease, Entamoeba histolytica neutral thiol proteinase) is an enzyme.^[1]^[2] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including basement membrane collagen and azocasein. Preferential cleavage: Arg-Arg- in small molecule substrates including Z-Arg-Arg-!NHMec

This enzyme is present in the protozoan, Entamoeba histolytica.

References

↑ Lushbaugh, W.B., Hofbauer, A.F. and Pittman, F.E. (1985). "Entamoeba histolytica: purification of cathepsin B". Exp. Parasitol. 59: 328–336. doi:10.1016/0014-4894(85)90088-8. PMID 2860002.
↑ Luaces, A.L. and Barrett, A.J. (1988). "Affinity purification and biochemical characterization of histolysin: the major cysteine proteinase of Entamoeba histolytica". Biochem. J. 250: 903–909. PMID 2898937.

External links

Histolysain at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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