ICI-199,441
 | |
| Systematic (IUPAC) name | |
|---|---|
|
2-(3,4-dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]acetamide | |
| Identifiers | |
| CAS Number |
115199-84-3  |
| PubChem | CID 3082718 |
| ChEMBL |
CHEMBL38576  |
| Chemical data | |
| Formula | C21H24Cl2N2O |
| Molar mass | 391.333 g/mol |
| |
| (what is this?) (verify) | |
ICI-199,441 is a drug which acts as a potent and selective κ-opioid agonist, and has analgesic effects.[1][2] It is a biased agonist of the KOR, and is one of a relatively few KOR ligands that is G protein-biased rather than β-arrestin-biased.
See also
References
- ↑ Costello GF, Main BG, Barlow JJ, Carroll JA, Shaw JS (July 1988). "A novel series of potent and selective agonists at the opioid kappa-receptor". European Journal of Pharmacology 151 (3): 475–8. doi:10.1016/0014-2999(88)90546-8. PMID 2850924.
- ↑ Narita M, Kaneko C, Miyoshi K, Nagumo Y, Kuzumaki N, Nakajima M, Nanjo K, Matsuzawa K, Yamazaki M, Suzuki T (April 2006). "Chronic pain induces anxiety with concomitant changes in opioidergic function in the amygdala". Neuropsychopharmacology 31 (4): 739–50. doi:10.1038/sj.npp.1300858. PMID 16123756.
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