Idrocilamide

Idrocilamide

Systematic (IUPAC) name
N-(2-Hydroxyethyl)-3-phenyl-2-propenamide
Clinical data
Trade names	Talval, Srilane, Relaxnova, Brolitène
AHFS/Drugs.com	International Drug Names
Routes of administration	Topical
Identifiers
CAS Number	6961-46-2
ATC code	M02AX05 (WHO)
PubChem	CID 1550874
ChemSpider	1267352
UNII	6C816LUB1O
ChEMBL	CHEMBL102358
Chemical data
Formula	C11H13NO2
Molar mass	191.226 g/mol
SMILES O=C(\C=C\c1ccccc1)NCCO
InChI InChI=1S/C11H13NO2/c13-9-8-12-11(14)7-6-10-4-2-1-3-5-10/h1-7,13H,8-9H2,(H,12,14)/b7-6+ Key:OSCTXCOERRNGLW-VOTSOKGWSA-N
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Idrocilamide (trade names Talval, Srilane, Relaxnova, Brolitène^[1]) is a medication with skeletal muscle relaxant^[2] and anti-inflammatory actions^[3] used as a topical cream to treat lumbago and other kinds of muscular pain;^[4] it is available on prescription or over-the-counter in France and various other countries.^[1]

Interactions

Idrocilamide has been reported to be a potent inhibitor of the metabolism of caffeine.^[5][6]

References

1. Drugs.com: International Drug Names
2. Bouron, A.; Rivet, M.; Nasri-Sebdani, M.; Guillemain, J.; Durbin, P.; Guerrier, D.; Raymond, G. (1990). "The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers". Canadian Journal of Physiology and Pharmacology 68 (12): 1503–1509. doi:10.1139/y90-228. PMID 2085796.
3. Bannwarth B, Le Huec JC, Vinçon G, et al. (December 1993). "[Tissue and systemic diffusion of idrocilamide after cutaneous administration]". Rev Rhum Ed Fr (in French) 60 (12): 932–6. PMID 8012322.
4. Stehman, M.; Lehert, P. (1990). "Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago". Acta Belgica. Medica physica : organe officiel de la Societe royale belge de medecine physique et de rehabilitation 13 (1): 29–32. PMID 2140002.
5. Carrillo JA, Benitez J (August 2000). "Clinically significant pharmacokinetic interactions between dietary caffeine and medications". Clin Pharmacokinet 39 (2): 127–53. doi:10.2165/00003088-200039020-00004. PMID 10976659.
6. Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC (January 1980). "Inhibition by idrocilamide of the disposition of caffeine". Eur. J. Clin. Pharmacol. 17 (1): 37–43. doi:10.1007/bf00561675. PMID 7371698.