IgA-specific metalloendopeptidase

IgA-specific metalloendopeptidase
Identifiers
EC number	3.4.24.13
CAS number	72231-73-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

IgA-specific metalloendopeptidase (EC 3.4.24.13, immunoglobulin A1 proteinase, IgA protease, IgA1-specific proteinase, IgA1 protease, IgA1 proteinase) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

Cleavage of Pro-Thr bond in the hinge region of the heavy chain of human immunoglobulin A

This enzyme is present in several pathogenic species of Streptococcus.

Other species, for instance bacteria that cause meningitis, gonorrhea, some cases of pneumonia, sinusitis and ear infections also produce an enzyme that cleaves IgA, but this is a serine protease and is metal-independent.^[4]

References

1. Kornfeld, S.J. and Plaut, A.G. (1981). "Secretory immunity and the bacterial IgA proteases". Rev. Infect. Dis. 3: 521–534. doi:10.1093/clinids/3.3.521. PMID 6792682.
2. Gilbert, J.V., Plaut, A.G. and Wright, A. (1991). "Analysis of the immunoglobulin A protease gene of Streptococcus sanguis". Infect. Immun. 59: 7–17. PMID 1987065.
3. Gilbert, J.V., Plaut, A.G., Fishman, Y. and Wright, A. (1988). "Cloning of the gene encoding streptococcal immunoglobulin A protease and its expression in Escherichia coli". Infect. Immun. 56: 1961–1966. PMID 3294181.
4. Parsons, H. K.; Vitovski, S; Sayers, J. R. (2004). "Immunoglobulin A1 proteases: A structure-function update". Biochemical Society Transactions 32 (Pt 6): 1130–2. doi:10.1042/BST0321130. PMID 15506988.

External links

• IgA-specific metalloendopeptidase at the US National Library of Medicine Medical Subject Headings (MeSH)