J147
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| Systematic (IUPAC) name | |
|---|---|
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N-(2,4-dimethylphenyl)-2,2,2-trifluoro-N-[(E)-(3-methoxyphenyl)methylideneamino]acetamide | |
| Clinical data | |
| Legal status |
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| Identifiers | |
| CAS Number | 1146963-51-0 |
| PubChem | CID 25229652 |
| ChemSpider | 29341612 |
| Chemical data | |
| Formula | C18H17F3N2O2 |
| Molar mass | 350.34 g·mol−1 |
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J147 is an experimental drug with reported effects against both Alzheimer's disease and ageing in mouse models of accelerated aging.[1][2][3][4]
The approach that lead to development of the J147 drug was to screen candidate molecules for anti-aging effects, instead of targeting the amyloid plaques. It is contrary to the most of other approaches to develop drugs against the Alzheimer's disease that target the plaque deposits in the brain.[5]
The J147 drug is also reported to address other biological aging factors, such as preventing the leakage of blood from microvessels in mice brains.[5] The development of J147 follows the chemical pharmacological way, contrary to biological ways that exploit e.g. use of bacteriophages.[6][7]
References
- ↑ "Experimental drug targeting Alzheimer's disease shows anti-aging effects" (Press release). Salk Institute. 12 November 2015. Retrieved November 13, 2015.
- ↑ Chen Q, Prior M, Dargusch R, Roberts A, Riek R, Eichmann C, Chiruta C, Akaishi T, Abe K, Maher P, Schubert D (14 December 2011). "A novel neurotrophic drug for cognitive enhancement and Alzheimer's disease". PLoS One 6 (12): e27865. doi:10.1371/journal.pone.0027865. PMC 3237323. PMID 22194796.
- ↑ Currais A, Goldberg J, Farrokhi C, Chang M, Prior M, Dargusch R, Daugherty D, Armando A, Quehenberger O, Maher P, Schubert D (11 November 2015). "A comprehensive multiomics approach toward understanding the relationship between aging and dementia" (PDF). Aging 7 (11). PMID 26564964.
- ↑ Prior M, Dargusch R, Ehren JL, Chiruta C, Schubert D (May 2013). "The neurotrophic compound J147 reverses cognitive impairment in aged Alzheimer's disease mice". Alzheimer's Research & Therapy 5 (3): 25. doi:10.1186/alzrt179. PMID 23673233.
- 1 2 Brian L. Wang (13 November 2015). "Experimental drug targeting Alzheimer's disease shows anti-aging effects in animal tests". nextbigfuture.com. Retrieved November 16, 2015.
- ↑ Krishnan R, Tsubery H, Proschitsky MY, Asp E, Lulu M, Gilead S, Gartner M, Waltho JP, Davis PJ, Hounslow AM, Kirschner DA, Inouye H, Myszka DG, Wright J, Solomon B, Fisher RA. "A bacteriophage capsid protein provides a general amyloid interaction motif (GAIM) that binds and remodels misfolded protein assemblies.". Journal of Molecular Biology. PMID 24768993.
- ↑ Solomon B (October 2008). "Filamentous bacteriophage as a novel therapeutic tool for Alzheimer's disease treatment". Journal of Alzheimer's Disease 15 (2). PMID 18953108.
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