Hepatic fructokinase

ketohexokinase (fructokinase)
Identifiers
Symbol KHK
Entrez 3795
HUGO 6315
OMIM 229800
RefSeq NM_006488
UniProt P50053
Other data
EC number 2.7.1.3
Locus Chr. 2 p23.3-23.2
Ketohexokinase
Identifiers
EC number 2.7.1.3
CAS number 9030-50-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Hepatic fructokinase (or ketohexokinase ) is an enzyme that catalyzes the phosphorylation of fructose to produce fructose-1-phosphate.


ATP +  \longrightarrow  ADP +
ATP + D-fructose → ADP + D-fructose-1-phosphate[1]

Pathology

A deficiency is associated with essential fructosuria.

References

  1. Bais R, James HM, Rofe AM, Conyers RA (1985). "The purification and properties of human liver ketohexokinase. A role for ketohexokinase and fructose-bisphosphate aldolase in the metabolic production of oxalate from xylitol". Biochem. J. 230 (1): 53–60. PMC 1152585. PMID 2996495.

External links

This article is issued from Wikipedia - version of the Saturday, April 02, 2016. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.