L-peptidase

L-peptidase
Identifiers
EC number	3.4.22.46
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

L-peptidase (EC 3.4.22.46) is an enzyme.^[1][2] This enzyme catalyses the following chemical reaction

Autocatalytically cleaves itself from the polyprotein of the foot-and-mouth disease virus by hydrolysis of a Lys-Gly bond. Subsequently, it cleaves host cell initiation factor eIF-4G at bonds -Gly-Arg- and -Lys-Arg-

This enzyme is coded bz foot-and-mouth disease virus.

References

1. Piccone, M.E., Zellner, M., Kumosinski, T.F., Mason, P.W. and Grubman, M.J. (1995). "Identification of the active-site residues of the L proteinase of foot-and-mouth disease virus". J. Virol. 69: 4950–4956. PMID 7609064.
2. Guarné, A., Hampoelz, B., Glaser, W., Carpena, X., Torma, J., Fita, I. and Skern, T. (2000). "Structural and biochemical features distinguish the foot-and-mouth disease virus leader proteinase from other papain-like enzymes". J. Mol. Biol. 302: 1227–1240. doi:10.1006/jmbi.2000.4115. PMID 11183785.

External links

• L-peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)