Legumain

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Legumain (EC 3.4.22.34, asparaginyl endopeptidase, citvac, proteinase B, hemoglobinase, PRSC1 gene product or LGMN (Homo sapiens), vicilin peptidohydrolase, bean endopeptidase) is an enzyme^[1]^[2]^[3] that in humans is encoded by the LGMN gene (previous symbol PRSC1). This enzyme catalyses the following chemical reaction

Hydrolysis of proteins and small molecule substrates at -Asn-Xaa- bonds

This enzyme is present in legume seeds, the trematode Schistosoma mansoni and mammalian lysosomes.

References

↑ Hara-Nishimura, I. (1998). "Asparaginyl endopeptidase". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 746–749.
↑ Dalton, J.P. and Brindley, P.J. (1998). "Schistosome legumain". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes. London: Academic Press. pp. 749–754.
↑ Chen, J.-M., Rawlings, N.D., Stevens, R.A.E. and Barrett, A.J. (1998). "Identification of the active site of legumain links it to caspases, clostripain and gingipains in a new clan of cysteine endopeptidases". FEBS Lett. 441: 361–365. doi:10.1016/S0014-5793(98)01574-9. PMID 9891971.

External links

Legumain at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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