Leishmanolysin

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Leishmanolysin (EC 3.4.24.36, promastigote surface endopeptidase, glycoprotein gp63, Leishmania metalloproteinase, surface acid proteinase, promastigote surface protease) is an enzyme.^[1]^[2]^[3]^[4] This enzyme catalyses the following chemical reaction

Preference for hydrophobic residues at P1 and P1' and basic residues at P2' and P3'. A model nonapeptide is cleaved at -Ala-Tyr-Leu-Lys-Lys-

This membrane-bound glycoprotein is present in the promastigote of various species of Leishmania protozoans.

References

↑ Button, L.L. and McMaster, W.R. (1988). "Molecular cloning of the major surface antigen of Leishmania". J. Exp. Med. 167: 724–729. doi:10.1084/jem.167.2.724. PMID 3346625.
↑ Bouvier, J., Cordier, C., Vogel, H., Reichelt, R. and Etges, R. (1989). "Characterization of the promastigote surface protease of Leishmania as a membrane-bound zinc endopeptidase". Mol. Biochem. Parasitol. 37: 235–246. doi:10.1016/0166-6851(89)90155-2. PMID 2608099.
↑ Chaudhuri, G., Chaudhuri, M., Pan, A. and Chang, K.-P. (1989). "Surface acid proteinase (gp63) of Leishmania mexicana. A metalloenzyme capable of protecting liposome-encapsulated proteins from phagolysosomal degradation by macrophages". J. Biol. Chem. 264: 7483–7489. PMID 2708373.
↑ Bouvier, J., Schneider, P., Etges, R. and Bordier, C. (1990). "Peptide substrate specificity of the membrane-bound metalloprotease of Leishmania". Biochemistry 29: 10113–10119. doi:10.1021/bi00495a015. PMID 2271643.

External links

Leishmanolysin at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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