Lucey–Driscoll syndrome

Lucey–Driscoll syndrome
Classification and external resources
ICD-9-CM	774.30
OMIM	237900
DiseasesDB	32677

Lucey–Driscoll syndrome is an autosomal recessive metabolic disorder affecting enzymes involved in bilirubin metabolism. It is one of several disorders classified as a transient familial neonatal unconjugated hyperbilirubinemia.

Cause

The common cause is congenital, but it can also be caused by maternal steroids passed on through breast milk to the newborn. It is different from breast feeding-associated jaundice (breast-fed infants have higher bilirubin levels than formula-fed ones).

Genetics

Lucey–Driscoll syndrome has an autosomal recessive pattern of inheritance.

A defect in the UGT1A1-gene, also linked to Crigler–Najjar syndrome and Gilbert's syndrome, is responsible for the congenital form of Lucey–Driscoll syndrome.

External links

Online 'Mendelian Inheritance in Man' (OMIM) 237900 - transient familial neonatal hyperbilirubinemia, breast feeding jaundice included
Hyperbilirubinemia, Unconjugated at eMedicine
Lucey Driscoll syndrome at NIH's Office of Rare Diseases

Heme metabolism disorders (E80, 277.1, 277.4)

Porphyria,
hepatic and erythropoietic
(porphyrin)

early mitochondrial:	ALAD porphyria Acute intermittent porphyria

cytoplasmic:	Gunther disease/congenital erythropoietic porphyria Porphyria cutanea tarda/Hepatoerythropoietic porphyria

late mitochondrial:	Hereditary coproporphyria Harderoporphyria Variegate porphyria Erythropoietic protoporphyria

Hereditary hyperbilirubinemia
(bilirubin)

unconjugated:	Gilbert's syndrome Crigler–Najjar syndrome Lucey–Driscoll syndrome

conjugated:	Dubin–Johnson syndrome Rotor syndrome

This article is issued from Wikipedia - version of the Monday, September 08, 2014. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.