MMP14

Matrix metallopeptidase 14 (membrane-inserted)
PDB rendering based on 1bqq.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1BQQ​, 1BUV​, 2MQS​, 3C7X​, 3MA2​, 4P3C​, 4P3D​, 4QXU​
Identifiers
Symbols	MMP14 ; MMP-14; MMP-X1; MT-MMP; MT-MMP 1; MT1-MMP; MT1MMP; MTMMP1; WNCHRS
External IDs	OMIM: 600754 MGI: 101900 HomoloGene: 21040 ChEMBL: 3869 GeneCards: MMP14 Gene
EC number	3.4.24.80
Gene ontology Molecular function • transcription factor activity, sequence-specific DNA binding • metalloendopeptidase activity • integrin binding • calcium ion binding • protein binding • zinc ion binding • peptidase activator activity Cellular component • cytoplasm • Golgi lumen • plasma membrane • integral component of plasma membrane • focal adhesion • extracellular matrix • cytoplasmic vesicle • melanosome • macropinosome Biological process • angiogenesis • ovarian follicle development • response to hypoxia • endothelial cell proliferation • endochondral ossification • regulation of transcription, DNA-templated • proteolysis • response to oxidative stress • male gonad development • response to mechanical stimulus • positive regulation of peptidase activity • extracellular matrix disassembly • extracellular matrix organization • positive regulation of cell growth • lung development • positive regulation of cell migration • collagen catabolic process • zymogen activation • endodermal cell differentiation • chondrocyte proliferation • astrocyte cell migration • response to estrogen • embryonic cranial skeleton morphogenesis • branching morphogenesis of an epithelial tube • tissue remodeling • negative regulation of focal adhesion assembly • craniofacial suture morphogenesis Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	4323	17387
Ensembl	ENSG00000157227	ENSMUSG00000000957
UniProt	P50281	P53690
RefSeq (mRNA)	NM_004995	NM_008608
RefSeq (protein)	NP_004986	NP_032634
Location (UCSC)	Chr 14: 22.84 – 22.85 Mb	Chr 14: 54.43 – 54.44 Mb
PubMed search

Matrix metalloproteinase-14 is an enzyme that in humans is encoded by the MMP14 gene.^[1]

Function

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive pro-proteins which are activated when cleaved by extracellular proteinases.

However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted.

"This protein activates MMP2 protein, and this activity may be involved in tumor invasion."^[2]

Interactions

MMP14 has been shown to interact with TIMP2.^[3]

See also

• Matrix metalloproteinase
• ARK5

References

1. Sato H, Takino T, Okada Y, Cao J, Shinagawa A, Yamamoto E, Seiki M (Jul 1994). "A matrix metalloproteinase expressed on the surface of invasive tumour cells". Nature 370 (6484): 61–5. doi:10.1038/370061a0. PMID 8015608.
2. "Entrez Gene: MMP14 matrix metallopeptidase 14 (membrane-inserted)".
3. Zucker S, Drews M, Conner C, Foda HD, DeClerck YA, Langley KE, Bahou WF, Docherty AJ, Cao J (Jan 1998). "Tissue inhibitor of metalloproteinase-2 (TIMP-2) binds to the catalytic domain of the cell surface receptor, membrane type 1-matrix metalloproteinase 1 (MT1-MMP)". J. Biol. Chem. 273 (2): 1216–22. doi:10.1074/jbc.273.2.1216. PMID 9422789.

Further reading

• Nagase H, Woessner JF (1999). "Matrix metalloproteinases.". J. Biol. Chem. 274 (31): 21491–4. doi:10.1074/jbc.274.31.21491. PMID 10419448.

External links

• The MEROPS online database for peptidases and their inhibitors: M10.014