Macrophage elastase

Macrophage elastase
Identifiers
EC number 3.4.24.65
CAS number 2594837
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum

Macrophage elastase (EC 3.4.24.65, metalloelastase, human macrophage metalloelastase (HME)) is an enzyme.[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at -Ala14-Leu- and -Tyr16-Leu- in the B chain of insulin

This enzyme belongs to the peptidase family M10.

References

  1. ↑ Banda, M.J. and Werb, Z. (1981). "Mouse macrophage elastase. Purification and characterization as a metalloproteinase". Biochem. J. 193: 589–605. PMID 7030312.
  2. ↑ Kettner, C., Shaw, E., White, R. and Janoff, A. (1981). "The specificity of macrophage elastase on the insulin B-chain". Biochem. J. 195: 369–372. PMID 7032505.
  3. ↑ Shapiro, S.D., Griffin, G.L., Gilbert, D.J., Jenkins, N.A., Copeland, N.G., Welgus, H.G., Senior, R.M. and Ley, T.J. (1992). "Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase". J. Biol. Chem. 267: 4664–4671. PMID 1537850.
  4. ↑ Shapiro, S.D., Kobayashi, D.K. and Ley, T.J. (1993). "Cloning and characterization of a unique elastolytic metalloproteinase produced by human alveolar macrophages". J. Biol. Chem. 268: 23824–23829. PMID 8226919.

See also

External links

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