Magnolysin

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Magnolysin (EC 3.4.24.62, bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-oxytocin/neurophysin convertase, prooxyphysin proteinase, pro-oxytocin convertase) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-Ala-Val-.

This endopeptidase is present in bovine pituitary neurosecretory granules.

References

↑ Clamagirand, C., Creminon, C., Fahy, C., Boussetta, H. and Cohen, P. (1987). "Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytosin/neurophysin peptides at the basic amino acid doublet". Biochemistry 26: 6018–6023. doi:10.1021/bi00393a011. PMID 2825769.
↑ Créminon, C., Rholam, M., Boussetta, H., Marrakchi, N. and Cohen, P. (1988). "Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme". J. Chromatogt. 440: 439–448. doi:10.1016/s0021-9673(00)94547-3. PMID 3042797.
↑ Brakch, N., Boussetta, H., Rholam, M. and Cohen, P. (1989). "Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model". J. Biol. Chem. 264: 15912–15916. PMID 2674120.
↑ Plevrakis, I, Créminon, C., Clamagirand, C., Brakch, N., Rholam, M. and Cohen, P. (1989). "Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor". Biochemistry 28: 2705–2710. doi:10.1021/bi00432a051. PMID 2659078.
↑ Guillou, M.D., Camier, M. and Clamagirand, C. (1994). "Evidence for the presence of pro-oxytocin/neurophysin converting enzyme in the human ovary". J. Endocrinol. 142: 345–352. doi:10.1677/joe.0.1420345. PMID 7931007.

External links

Magnolysin at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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