Melitidin

Melitidin

Properties
Chemical formula	C33H40O18
Molar mass	724.67 g·mol^−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Melitidin is a flavanone glycoside. Melitidin was discovered in bergamot orange juice and exhibits statin-like properties^[1][2] so the juice seems to have hypolipidemic activity.^[1][3][4][5]

References

1. Di Donna, Leonardo; De Luca, Giuseppina; Mazzotti, Fabio; Napoli, Anna; Salerno, Raffaele; Taverna, Domenico; Sindona, Giovanni (2009). "Statin-like Principles of Bergamot Fruit: Isolation of 3-Hydroxymethylglutaryl Flavonoid Glycosides". Journal of Natural Products 72 (7): 1352–1354. doi:10.1021/np900096w. PMID 19572741. Cite uses deprecated parameter |coauthors= (help)
2. Di Donna, Leonardo; Gallucci, Giselda; Malaj, Naim; Romano, Elvira; Tagarelli, Antonio; Sindona, Giovanni (2011). "Recycling of industrial essential oil waste: Brutieridin and Melitidin, two anticholesterolaemic active principles from bergamot albedo". Food Chemistry 125 (2): 438–441. doi:10.1016/j.foodchem.2010.09.025. ISSN 0308-8146.
3. Natalizia Miceli, M. R. Mondello, M. T. Monforte, V. Sdrafkakis, P. Dugo, M. L. Crupi, M. F. Taviano, R. De Pasquale and A. Trovato (2007). "Hypolipidemic Effects of Citrus bergamia Risso et Poiteau Juice in Rats Fed a Hypercholesterolemic Diet". J. Agric. Food Chem. 55 (27): 10671–10677. doi:10.1021/jf071772i.
4. Monica Leopoldini, N. Malaj, M. Toscano, G. Sindona, and N. Russo (2010). "On the Inhibitor Effects of Bergamot Juice Flavonoids Binding to the 3-Hydroxy-3-methylglutaryl-CoA Reductase (HMGR) Enzyme". J. Agric. Food Chem. 58 (19): 10768–10773. doi:10.1021/jf102576j.
5. Vincenzo Mollace, I. Sacco, E. Janda, C. Malara, D. Ventrice, C. Colica, V. Visalli, S. Muscoli, S. Ragusa, C. Muscoli, D. Rotirotia, F. Romeo (2011). "Hypolipemic and hypoglycaemic activity of bergamot polyphenols: From animal models to human studies". Fitoterapia 82 (3): 309–316. doi:10.1016/j.fitote.2010.10.014. PMID 21056640. PDF

Bibliography

• Zou, W; Wang Y; Liu H; Luo Y; Chen S; Su W (2013). "Melitidin: a flavanone glycoside from Citrus grandis 'Tomentosa'". Nat Prod Commun 8 (4): 457–458. PMID 23738451.
• Mencherini, Teresa; Campone, Luca; Piccinelli, Anna Lisa; García Mesa, Milagros; Sánchez, Dulce María; Aquino, Rita Patrizia; Rastrelli, Luca (2013). "HPLC-PDA-MS and NMR Characterization of a Hydroalcoholic Extract of Citrus aurantium L. var.amara Peel with Antiedematogenic Activity". Journal of Agricultural and Food Chemistry 61 (8): 1686–1693. doi:10.1021/jf302815t. ISSN 0021-8561.
• Barreca, Davide; Bellocco, Ersilia; Caristi, Corrado; Leuzzi, Ugo; Gattuso, Giuseppe (2011). "Distribution of C- and O-glycosyl flavonoids, (3-hydroxy-3-methylglutaryl)glycosyl flavanones and furocoumarins in Citrus aurantium L. juice". Food Chemistry 124 (2): 576–582. doi:10.1016/j.foodchem.2010.06.076. ISSN 0308-8146.
• Di Donna, Leonardo; Taverna, Domenico; Mazzotti, Fabio; Benabdelkamel, Hicham; Attya, Mohamed; Napoli, Anna; Sindona, Giovanni (2013). "Comprehensive assay of flavanones in citrus juices and beverages by UHPLC–ESI-MS/MS and derivatization chemistry". Food Chemistry 141 (3): 2328–2333. doi:10.1016/j.foodchem.2013.05.034. ISSN 0308-8146.

See also

• Brutieridin