Meprin B

Meprin B
Identifiers
EC number	3.4.24.63
CAS number	150679-52-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Meprin B (EC 3.4.24.63, meprin-b) is an enzyme.^[1][2][3][4] This enzyme catalyses the following chemical reaction

Hydrolysis of proteins, including azocasein, and peptides. Hydrolysis of -His⁵-Leu-, -Leu⁶-Cys-, -Ala¹⁴-Leu- and -Cys¹⁹-Gly- bonds in insulin B chain

This membrane-bound metalloendopeptidase is present in mouse intestines.

References

1. Kounnas, M.Z., Wolz, R.L., Gorbea, C.M. and Bond, J.S. (1991). "Meprin-A and -B. Cell surface endopeptidases of the mouse kidney". J. Biol. Chem. 266: 17350–17357. PMID 1894622.
2. Gorbea, C.M., Marchand, P., Jiang, W., Copeland, N.G., Gilbert, D.J., Jenkins, N.A. and Bond, J.S. (1993). "Cloning, expression, and chromosomal localization of the mouse meprin β subunit". J. Biol. Chem. 268: 21035–21043. PMID 8407940.
3. Johnson, G.D. and Hersh, L.B. (1994). "Expression of meprin subunit precursors. Membrane anchoring through the β subunit and mechanism of zymogen activation". J. Biol. Chem. 269: 7682–7688. PMID 7510289.
4. Wolz, R.L. and Bond, J.S. (1995). "Meprins A and B". Methods Enzymol. 248: 325–345. doi:10.1016/0076-6879(95)48022-6. PMID 7674930.

External links

• Meprin B at the US National Library of Medicine Medical Subject Headings (MeSH)