Mitochondrial processing peptidase

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Mitochondrial processing peptidase (EC 3.4.24.64, processing enhancing peptidase (for one of two subunits), mitochondrial protein precursor-processing proteinase, matrix peptidase, matrix processing peptidase, matrix processing proteinase, MPP) is an enzyme.^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

Release of N-terminal targetting peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2

This enzyme is present the mitochondrial matrix of fungi and mammals.

References

↑ Jensen, R.E. and Yaffe, M.P. (1988). "Import of proteins into yeast mitochondria: the nuclear MAS2 gene encodes a component of the processing protease that is homologous to the MAS1-encoded subunit". EMBO J. 7: 3863–3871. PMID 3061808.
↑ Witte, C., Jensen, R.E., Yaffe, M.P. and Schatz, G. (1988). "MAS1, a gene essential for yeast mitochondrial assembly, encodes a subunit of the mitochondrial processing protease". EMBO J. 7: 1439–1447. PMID 3044780.
↑ Rawlings, N.D. and Barrett, A.J. (1991). "Homologues of insulinase, a new superfamily of metalloendopeptidases". Biochem. J. 275: 389–391. PMID 2025223.
↑ Kalousek, F., Neupert, W., Omura, T., Schatz, G. and Schmitz, U.K. (1993). "Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins". Trends Biochem. Sci. 18: 249–249. doi:10.1016/0968-0004(93)90174-l. PMID 8212133.
↑ Brunner, M. and Neupert, W. (1994). "Purification and characterization of the mitochondrial processing peptidase of Neurospora crassa". Methods Enzymol. 248: 717–728. doi:10.1016/0076-6879(95)48048-x.

External links

Mitochondrial processing peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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