Nitroscanate

Nitroscanate
Systematic (IUPAC) name


1-(4-Isothiocyanatophenoxy)-4-nitrobenzene
Clinical data
Trade names	Lopatol
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Number	19881-18-6
ATCvet code	QP52AX01
ChemSpider	61821
UNII	P4IE5B6D6U^Y
KEGG	D05193^Y
Chemical data
Formula	C₁₃H₈N₂O₃S
Molar mass	272.28 g/mol
SMILES C1=CC(=CC=C1N=C=S)OC2=CC=C(C=C2)[N+](=O)[O-]
InChI InChI=1S/C13H8N2O3S/c16-15(17)11-3-7-13(8-4-11)18-12-5-1-10(2-6-12)14-9-19/h1-8H Key:SVMGVZLUIWGYPH-UHFFFAOYSA-N
(verify)

Nitroscanate (trade name Lopatol) is an anthelmintic drug used in veterinary medicine to treat Toxocara canis, Toxascaris leonina, Ancylostoma caninum, Uncinaria stenocephala, Taenia, and Dipylidium caninum (roundworms, hookworms and tapeworms).^[1]^[2]

References

↑ "Lopatol (package insert)". Novartis. Retrieved 27 December 2013.
↑ Craig, T. M.; Mercer, S. H.; Wade, C. G.; Lynn, R. C. (1991). "Efficacy of nitroscanate against naturally acquired infection with Ancylostoma caninum, Dipylidium caninum, and Trichuris vulpis in dogs". American journal of veterinary research 52 (4): 574–575. PMID 2053726.

Antiparasitics – Anthelmintics (P02) and Endectocides (QP54)

Antiplatyhelmintic agents

Antitrematodals
(schistosomicides)

Binds tubulin	benzimidazole Triclabendazole^#

AI	phosphonic acid Metrifonate^‡

Other/unknown	quinoline Praziquantel^# Oxamniquine^# phenol Bithionol thiazole Niridazole arylsulfonate Stibophen

Anticestodals
(taeniacides)

Binds tubulin	benzimidazole Albendazole^#

Other/unknown	quinoline Praziquantel^# salicylanilide Niclosamide^# aminoacridine Quinacrine butyrophenone Desaspidin chlorophenol Dichlorophen

Antinematodal agents
(including
macrofilaricides)

Binds tubulin	benzimidazole Mebendazole^# Albendazole^# Tiabendazole Fenbendazole Ciclobendazole Flubendazole

Glutamate-gated chloride channel, GABA receptor	avermectins Abamectin Doramectin Emamectin Ivermectin^# Selamectin milbemycins Moxidectin Milbemycin oxime

NMDA	tetrahydropyrimidine Pyrantel^# pyrantel pamoate Oxantel

Other/unknown	piperazine Piperazine Diethylcarbamazine^# thiazole Levamisole^‡# quinolinium Pyrvinium benzylammonium Bephenium naphthalenesulfonate Suramin^# Tribendimidine

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

This article is issued from Wikipedia - version of the Friday, August 28, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.