Pappalysin-1

Pappalysin-1
Identifiers
EC number	3.4.24.79
CAS number	151662-33-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Pappalysin-1 (EC 3.4.24.79, insulin-like growth factor binding protein-4 protease, pregnancy-associated plasma protein-A) is an enzyme.^[1][2] This enzyme catalyses the following chemical reaction

Cleavage of the Met¹³⁵-Lys bond in insulin-like growth factor binding protein (IGFBP)-4, and the Ser1⁴³-Lys bond in IGFBP-5

This enzyme belongs to the peptidase family M43.

See also

• Pregnancy-associated plasma protein A

References

1. Lawrence, J.B., Oxvig, C., Overgaard, M.T., Sottrup-Jensen, L., Gleich, G.J. (1999). ", Hays L.G., Yates, J.R. 3rd, and Conover, C.A. The insulin-like growth factor (IGF)-dependent IGF binding protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A". Proc. Natl. Acad. Sci. USA 96: 3149–3153. doi:10.1073/pnas.96.6.3149. PMC 15910. PMID 10077652.
2. Chen, B.K., Overgaard, M.T., Bale, L.K., Resch, Z.T., Christiansen, M., Oxvig, C. and Conover, C.A. (2002). "Molecular regulation of the IGF-binding protein-4 protease system in human fibroblasts: identification of a novel inducible inhibitor". Endocrinology 143: 1199–1205. doi:10.1210/endo.143.4.8729. PMID 11897673.

External links

• Pappalysin-1 at the US National Library of Medicine Medical Subject Headings (MeSH)