Diflorasone

Diflorasone
Systematic (IUPAC) name
[17-(2-Acetyloxyacetyl)- 6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16- octahydrocyclopenta[a]phenanthren-17-yl] acetate
Clinical data
Trade names Psorcon
AHFS/Drugs.com monograph
MedlinePlus a602019
Pregnancy
category
  • US: C (Risk not ruled out)
Legal status
Routes of
administration
Topical
Identifiers
CAS Number 2557-49-5 N
ATC code D07AC10
PubChem CID 71414
IUPHAR/BPS 7068
DrugBank DB00223 YesY
ChemSpider 64504 YesY
UNII T2DHJ9645W YesY
KEGG D01327 YesY
ChEBI CHEBI:31483 YesY
ChEMBL CHEMBL1201380 N
Chemical data
Formula C26H32F2O7
Molar mass 494.525 g/mol
 NYesY (what is this?)  (verify)

Diflorasone is a topical steroid that comes in the form of a cream containing diflorasone diacetate. In is manufactured by E. Fougera & Co. and is used as an anti-inflammatory and anti-itching agent, like other topical corticosteroids. It is prescribed for psoriasis[1] and atopic dermatitis, among other conditions. With respect to potency, it is regarded as a Class I steroid (of classes I–IV).[2]

No long-term animal studies have been done to determine whether diflorasone could have carcinogenic properties.

Little data is available regarding whether diflorasone would be present in great enough quantities to cause harm to an infant.[3]

References

  1. Shupack, J. L.; Jondreau, L.; Kenny, C.; Stiller, M. J. (1993). "Diflorasone diacetate ointment 0.05% versus betamethasone dipropionate ointment 0.05% in moderate-severe plaque-type psoriasis". Dermatology (Basel, Switzerland) 186 (2): 129–132. PMID 8428041.
  2. psoriasis.org: [www.psoriasis.org/sublearn03_mild_potency]
  3. Drugs.com: Diflorasone topical



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