Renal protein reabsorption

Renal protein reabsorption is the part of renal physiology that deals with the retrieval of filtered proteins, preventing them from disappearing from the body through the urine.

Almost all reabsorption takes place in the proximal tubule. Only ~1%^[1] is left in the final urine.

The proteins cross the apical membrane by endocytosis. They are subsequently degraded in lysosomes. The remaining free amino acids are transported across the basolateral membrane by amino acid transporters.^[1]

Overview table

Characteristics of oligopeptide reabsorption
Characteristic	proximal tubule			loop of Henle	Distal convoluted tubule	Collecting duct system
Characteristic	S1	S2	S3	loop of Henle	Distal convoluted tubule	Collecting duct system
reabsorption (%)	99^[1]
reabsorption (mmoles/day)
Concentration
apical transport	endocytosis^[1]
basolateral transport proteins	amino acid transporter^[1]
Other reabsorption features

References

1 2 3 4 5 Walter F., PhD. Boron. Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. ISBN 1-4160-2328-3. Page 798

Physiology of the kidneys and acid-base physiology

Renal function

Secretion	clearance Pharmacokinetics Clearance of medications Urine flow rate

Reabsorption	Solvent drag sodium chloride urea glucose oligopeptides protein

Renal function	Glomerular filtration rate Creatinine clearance Renal clearance ratio Urea reduction ratio Kt/V Standardized Kt/V Measures of dialysis Hemodialysis product PAH clearance (Effective renal plasma flow Extraction ratio)

Filtration	Renal blood flow Ultrafiltration Countercurrent exchange Filtration fraction

Hormones

Acid-base balance

Body water: Intracellular fluid/Cytosol

Buffering

Other

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