SARS coronavirus main proteinase

SARS coronavirus main proteinase
Identifiers
EC number	3.4.22.69
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

SARS coronavirus main proteinase (EC 3.4.22.69, 3cLpro, 3C-like protease, coronavirus 3C-like protease, Mpro, SARS 3C-like protease, SARS coronavirus 3CL protease, SARS coronavirus main peptidase, SARS coronavirus main protease, SARS-CoV 3CLpro enzyme, SARS-CoV main protease, SARS-CoV Mpro, severe acute respiratory syndrome coronavirus main protease) is an enzyme.^[1][2][3] This enzyme catalyses the following chemical reaction

TSAVLQ-SGFRK-NH2 and SGVTFQ-!GKFKK are the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase

This protease is important in SARS coronavirus replicase polyprotein processing.

References

1. Goetz, D.H., Choe, Y., Hansell, E., Chen, Y.T., McDowell, M., Jonsson, C.B., Roush, W.R., McKerrow, J. and Craik, C.S. (2007). "Substrate specificity profiling and identification of a new class of inhibitor for the major protease of the SARS coronavirus". Biochemistry 46: 8744–8752. doi:10.1021/bi0621415. PMID 17605471.
2. Fan, K., Wei, P., Feng, Q., Chen, S., Huang, C., Ma, L., Lai, B., Pei, J., Liu, Y., Chen, J. and Lai, L. (2004). "Biosynthesis, purification, and substrate specificity of severe acute respiratory syndrome coronavirus 3C-like proteinase". J. Biol. Chem. 279: 1637–1642. doi:10.1074/jbc.m310875200. PMID 14561748.
3. Akaji, K., Konno, H., Onozuka, M., Makino, A., Saito, H. and Nosaka, K. (2008). "Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant". Bioorg. Med. Chem. 16: 9400–9408. doi:10.1016/j.bmc.2008.09.057. PMID 18845442.

External links

• SARS coronavirus main proteinase at the US National Library of Medicine Medical Subject Headings (MeSH)