SERPINB3

Serpin peptidase inhibitor, clade B (ovalbumin), member 3

Available structures

Ortholog search: PDBe, RCSB

List of PDB id codes
2ZV6

Identifiers

Symbols

SERPINB3 ; HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1; T4-A

External IDs

OMIM: 600517 MGI: 2683295 HomoloGene: 130559 GeneCards: SERPINB3 Gene

Gene ontology
Molecular function	• virus receptor activity • protease binding • serine-type endopeptidase inhibitor activity • cysteine-type endopeptidase inhibitor activity
Cellular component	• extracellular space • nucleus • cytoplasm • cytoplasmic vesicle • vesicle • extracellular exosome
Biological process	• positive regulation of cell proliferation • negative regulation of peptidase activity • positive regulation of epithelial to mesenchymal transition • positive regulation of endopeptidase activity • negative regulation of endopeptidase activity • positive regulation of cell migration • autocrine signaling • paracrine signaling • negative regulation of catalytic activity • negative regulation of JUN kinase activity • negative regulation of proteolysis • viral entry into host cell
Sources: Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

Chr 18:
63.64 – 63.66 Mb

Chr 1:
107.08 – 107.08 Mb

PubMed search

Serpin B3 is a protein that in humans is encoded by the SERPINB3 gene.^[1]^[2]

References

↑ Schneider SS, Schick C, Fish KE, Miller E, Pena JC, Treter SD, Hui SM, Silverman GA (May 1995). "A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene". Proc Natl Acad Sci U S A 92 (8): 3147–51. doi:10.1073/pnas.92.8.3147. PMC 42122. PMID 7724531.
↑ "Entrez Gene: SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3".

Suminami Y, Kishi F, Sekiguchi K, Kato H (1992). "Squamous cell carcinoma antigen is a new member of the serine protease inhibitors.". Biochem. Biophys. Res. Commun. 181 (1): 51–8. doi:10.1016/S0006-291X(05)81380-4. PMID 1958219.
Mino-Miyagawa N, Kimura Y, Hamamoto K (1990). "Tumor-antigen 4. Its immunohistochemical distribution and tissue and serum concentrations in squamous cell carcinoma of the lung and esophagus.". Cancer 66 (7): 1505–12. doi:10.1002/1097-0142(19901001)66:7<1505::AID-CNCR2820660712>3.0.CO;2-V. PMID 2208001.
Mino N, Iio A, Hamamoto K (1988). "Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs.". Cancer 62 (4): 730–4. doi:10.1002/1097-0142(19880815)62:4<730::AID-CNCR2820620415>3.0.CO;2-W. PMID 2840187.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Schick C, Pemberton PA, Shi GP, et al. (1998). "Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis.". Biochemistry 37 (15): 5258–66. doi:10.1021/bi972521d. PMID 9548757.
Cataltepe S, Gornstein ER, Schick C, et al. (2000). "Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas.". J. Histochem. Cytochem. 48 (1): 113–22. doi:10.1177/002215540004800112. PMID 10653592.
Uemura Y, Pak SC, Luke C, et al. (2000). "Circulating serpin tumor markers SCCA1 and SCCA2 are not actively secreted but reside in the cytosol of squamous carcinoma cells.". Int. J. Cancer 89 (4): 368–77. doi:10.1002/1097-0215(20000720)89:4<368::AID-IJC9>3.0.CO;2-6. PMID 10956412.
Hamada K, Shinomiya H, Asano Y, et al. (2001). "Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter.". Biochim. Biophys. Acta 1518 (1-2): 124–31. doi:10.1016/s0167-4781(01)00174-9. PMID 11267667.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Shimada H, Nabeya Y, Okazumi S, et al. (2003). "Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma.". Surgery 133 (5): 486–94. doi:10.1067/msy.2003.139. PMID 12773976.
Micke O, Bruns F, Schäfer U, et al. (2003). "The clinical value of squamous cell carcinoma antigen in patients irradiated for locally advanced cancer of the head and neck.". Anticancer Res. 23 (2A): 907–11. PMID 12820321.
Nawata S, Nakamura K, Hirakawa H, et al. (2004). "Electrophoretic analysis of the cleaved form of serpin, squamous cell carcinoma antigen-1 in normal and malignant squamous epithelial tissues.". Electrophoresis 24 (14): 2277–82. doi:10.1002/elps.200305501. PMID 12874860.
Masumoto K, Sakata Y, Arima K, et al. (2003). "Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1.". J. Biol. Chem. 278 (46): 45296–304. doi:10.1074/jbc.M307741200. PMID 12949073.
Moore PL, Ong S, Harrison TJ (2004). "Squamous cell carcinoma antigen 1-mediated binding of hepatitis B virus to hepatocytes does not involve the hepatic serpin clearance system.". J. Biol. Chem. 278 (47): 46709–17. doi:10.1074/jbc.M302842200. PMID 12975381.
Onishi A, Nakashiro K, Mihara M, et al. (2004). "Basic and clinical studies on quantitative analysis of lymph node micrometastasis in oral cancer.". Oncol. Rep. 11 (1): 33–9. doi:10.3892/or.11.1.33. PMID 14654899.
Hirakawa H, Nawata S, Sueoka K, et al. (2004). "Regulation of squamous cell carcinoma antigen production by E-cadherin mediated cell-cell adhesion in squamous cell carcinoma cell line.". Oncol. Rep. 11 (2): 415–9. doi:10.3892/or.11.2.415. PMID 14719077.
Pontisso P, Calabrese F, Benvegnù L, et al. (2004). "Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma.". Br. J. Cancer 90 (4): 833–7. doi:10.1038/sj.bjc.6601543. PMC 2410161. PMID 14970861.
Ruvoletto MG, Tono N, Carollo D, et al. (2004). "Surface expression of squamous cell carcinoma antigen (SCCA) can be increased by the preS1(21-47) sequence of hepatitis B virus.". J. Gen. Virol. 85 (Pt 3): 621–4. doi:10.1099/vir.0.19130-0. PMID 14993646.

Turato, C; Ruvoletto, MG; Biasiolo, A; et al. (Mar 2009). "Squamous cell carcinoma antigen-1 (SERPINB3) polymorphism in chronic liver disease". Dig Liver Dis. 41 (3): 212–6. doi:10.1016/j.dld.2008.06.001.

External links

The MEROPS online database for peptidases and their inhibitors: I04.008
SERPINB3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

Serpins

inhibitory	Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-antiplasmin Antithrombin C1-inhibitor Heparin cofactor II Protein C inhibitor Plasminogen activator inhibitor-1 Plasminogen activator inhibitor-2 Protein Z-related protease inhibitor SERPINA1 SERPINA2 SERPINA3 SERPINA4 SERPINA5 SERPINA6 SERPINA7 SERPINA8 SERPINA9 SERPINA14 SERPINB1 SERPINB2 SERPINB3 SERPINB4 SERPINB5 SERPINB6 SERPINB7 SERPINB8 SERPINB9 SERPINB13 SERPINC1 SERPIND1 SERPINE1 SERPINE2 SERPINE2 SERPINF1 SERPING1 SERPINH1 SERPINI1 SERPINI2

Cross class inhibitory	MENT SCCA-1 CrmA

noninhibitory	Heat shock protein 47 Maspin Ovalbumin SERPINF1 Thyroxine-binding globulin Transcortin SERPINF1

see also disorders of globin and globulin proteins

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SERPINB3

See also

References

Further reading

External links