SERPINB9

Serpin peptidase inhibitor, clade B (ovalbumin), member 9
Identifiers
Symbols	SERPINB9 ; CAP-3; CAP3; PI-9; PI9
External IDs	OMIM: 601799 MGI: 106603 HomoloGene: 37888 GeneCards: SERPINB9 Gene
Gene ontology Molecular function • protease binding • serine-type endopeptidase inhibitor activity • protein binding • cysteine-type endopeptidase inhibitor activity involved in apoptotic process Cellular component • extracellular space • intracellular • nucleus • cytoplasm • cytosol • membrane • extracellular exosome Biological process • mast cell mediated immunity • apoptotic process • immune response • response to bacterium • positive regulation of gene expression • negative regulation of endopeptidase activity • negative regulation by symbiont of host apoptotic process • protection from natural killer cell mediated cytotoxicity • negative regulation of apoptotic process • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • cellular response to estrogen stimulus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5272	20723
Ensembl	ENSG00000170542	ENSMUSG00000045827
UniProt	P50453	O08797
RefSeq (mRNA)	NM_004155	NM_009256
RefSeq (protein)	NP_004146	NP_033282
Location (UCSC)	Chr 6: 2.89 – 2.9 Mb	Chr 13: 33 – 33.02 Mb
PubMed search

Serpin B9 is a protein that in humans is encoded by the SERPINB9 gene.^[1][2][3]

PI9 belongs to the large superfamily of serine proteinase inhibitors (serpins), which bind to and inactivate serine proteinases. These interactions are involved in many cellular processes, including coagulation, fibrinolysis, complement fixation, matrix remodeling, and apoptosis (Sprecher et al., 1995).[supplied by OMIM]^[3]

See also

• Serpin

References

1. Sprecher CA, Morgenstern KA, Mathewes S, Dahlen JR, Schrader SK, Foster DC, Kisiel W (Jan 1996). "Molecular cloning, expression, and partial characterization of two novel members of the ovalbumin family of serine proteinase inhibitors". J Biol Chem 270 (50): 29854–61. doi:10.1074/jbc.270.50.29854. PMID 8530382.
2. Sun J, Stephens R, Mirza G, Kanai H, Ragoussis J, Bird PI (Feb 1999). "A serpin gene cluster on human chromosome 6p25 contains PI6, PI9 and ELANH2 which have a common structure almost identical to the 18q21 ovalbumin serpin genes". Cytogenet Cell Genet 82 (3–4): 273–7. doi:10.1159/000015118. PMID 9858835.
3. "Entrez Gene: SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9".

Further reading

• Sun J, Bird CH, Sutton V, et al. (1996). "A cytosolic granzyme B inhibitor related to the viral apoptotic regulator cytokine response modifier A is present in cytotoxic lymphocytes". J. Biol. Chem. 271 (44): 27802–9. doi:10.1074/jbc.271.44.27802. PMID 8910377.
• Annand RR, Dahlen JR, Sprecher CA, et al. (1999). "Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the human serpin analogue proteinase inhibitor 9". Biochem. J. 342 Pt 3 (3): 655–65. doi:10.1042/0264-6021:3420655. PMC 1220507. PMID 10477277.
• Kanamori H, Krieg S, Mao C, et al. (2000). "Proteinase inhibitor 9, an inhibitor of granzyme B-mediated apoptosis, is a primary estrogen-inducible gene in human liver cells". J. Biol. Chem. 275 (8): 5867–73. doi:10.1074/jbc.275.8.5867. PMID 10681578.
• Bladergroen BA, Strik MC, Bovenschen N, et al. (2001). "The granzyme B inhibitor, protease inhibitor 9, is mainly expressed by dendritic cells and at immune-privileged sites". J. Immunol. 166 (5): 3218–25. doi:10.4049/jimmunol.166.5.3218. PMID 11207275.
• Buzza MS, Hirst CE, Bird CH, et al. (2001). "The granzyme B inhibitor, PI-9, is present in endothelial and mesothelial cells, suggesting that it protects bystander cells during immune responses". Cell. Immunol. 210 (1): 21–9. doi:10.1006/cimm.2001.1806. PMID 11485349.
• Hirst CE, Buzza MS, Sutton VR, et al. (2002). "Perforin-independent expression of granzyme B and proteinase inhibitor 9 in human testis and placenta suggests a role for granzyme B-mediated proteolysis in reproduction". Mol. Hum. Reprod. 7 (12): 1133–42. doi:10.1093/molehr/7.12.1133. PMID 11719590.
• Tanaka K, Harashima N, Niiya F, et al. (2002). "Serine proteinase inhibitor 9 can be recognized by cytotoxic T lymphocytes of epithelial cancer patients". Jpn. J. Cancer Res. 93 (2): 198–208. doi:10.1111/j.1349-7006.2002.tb01259.x. PMID 11856484.
• ten Berge RL, Meijer CJ, Dukers DF, et al. (2002). "Expression levels of apoptosis-related proteins predict clinical outcome in anaplastic large cell lymphoma". Blood 99 (12): 4540–6. doi:10.1182/blood.V99.12.4540. PMID 12036886.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Hirst CE, Buzza MS, Bird CH, et al. (2003). "The intracellular granzyme B inhibitor, proteinase inhibitor 9, is up-regulated during accessory cell maturation and effector cell degranulation, and its overexpression enhances CTL potency". J. Immunol. 170 (2): 805–15. doi:10.4049/jimmunol.170.2.805. PMID 12517944.
• Rowshani AT, Florquin S, Bemelman F, et al. (2005). "Hyperexpression of the granzyme B inhibitor PI-9 in human renal allografts: a potential mechanism for stable renal function in patients with subclinical rejection". Kidney Int. 66 (4): 1417–22. doi:10.1111/j.1523-1755.2004.00903.x. PMID 15458434.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Mahrus S, Kisiel W, Craik CS (2005). "Granzyme M is a regulatory protease that inactivates proteinase inhibitor 9, an endogenous inhibitor of granzyme B". J. Biol. Chem. 279 (52): 54275–82. doi:10.1074/jbc.M411482200. PMID 15494398.
• Classen CF, Ushmorov A, Bird P, Debatin KM (2006). "The granzyme B inhibitor PI-9 is differentially expressed in all main subtypes of pediatric acute lymphoblastic leukemias". Haematologica 89 (11): 1314–21. PMID 15531453.
• Bruneel A, Labas V, Mailloux A, et al. (2006). "Proteomics of human umbilical vein endothelial cells applied to etoposide-induced apoptosis". Proteomics 5 (15): 3876–84. doi:10.1002/pmic.200401239. PMID 16130169.
• van Houdt IS, Oudejans JJ, van den Eertwegh AJ, et al. (2005). "Expression of the apoptosis inhibitor protease inhibitor 9 predicts clinical outcome in vaccinated patients with stage III and IV melanoma". Clin. Cancer Res. 11 (17): 6400–7. doi:10.1158/1078-0432.CCR-05-0306. PMID 16144945.
• Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.014
• SERPINB9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.