SERPINE2

Serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 4DY0​, 4DY7​
Identifiers
Symbols	SERPINE2 ; GDN; GDNPF; PI-7; PI7; PN-1; PN1; PNI
External IDs	OMIM: 177010 MGI: 101780 HomoloGene: 21247 GeneCards: SERPINE2 Gene
Gene ontology Molecular function • serine-type endopeptidase inhibitor activity • receptor binding • protein binding • glycosaminoglycan binding • heparin binding Cellular component • extracellular region • extracellular space • cytosol • extracellular matrix • platelet alpha granule • extrinsic component of external side of plasma membrane • neuromuscular junction • neuronal cell body • extracellular vesicle Biological process • embryo implantation • blood coagulation • negative regulation of cell proliferation • response to radiation • negative regulation of plasminogen activation • negative regulation of sodium ion transport • negative regulation of endopeptidase activity • negative regulation of protein processing • positive regulation of neuron projection development • negative regulation of phosphatidylinositol 3-kinase signaling • cerebellar granular layer morphogenesis • negative regulation of blood coagulation • negative regulation of cell growth • regulation of cell migration • secretory granule organization • mating plug formation • negative regulation of proteolysis • negative regulation of smoothened signaling pathway • regulation of timing of cell differentiation • positive regulation of astrocyte differentiation • detection of mechanical stimulus involved in sensory perception • regulation of synaptic transmission, glutamatergic • long-term synaptic potentiation • innervation • seminal vesicle epithelium development • dense core granule biogenesis • negative regulation of platelet aggregation Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5270	20720
Ensembl	ENSG00000135919	ENSMUSG00000026249
UniProt	P07093	Q07235
RefSeq (mRNA)	NM_001136528	NM_009255
RefSeq (protein)	NP_001130000	NP_033281
Location (UCSC)	Chr 2: 223.98 – 224.04 Mb	Chr 1: 79.79 – 79.86 Mb
PubMed search

Glia-derived nexin is a protein that in humans is encoded by the SERPINE2 gene.^[1][2]

See also

• Serpin

References

1. Carter RE, Cerosaletti KM, Burkin DJ, Fournier RE, Jones C, Greenberg BD, Citron BA, Festoff BW (Oct 1995). "The gene for the serpin thrombin inhibitor (PI7), protease nexin I, is located on human chromosome 2q33-q35 and on syntenic regions in the mouse and sheep genomes". Genomics 27 (1): 196–9. doi:10.1006/geno.1995.1025. PMID 7665170.
2. "Entrez Gene: SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2".

Further reading

• Naldini L, Tamagnone L, Vigna E, et al. (1993). "Extracellular proteolytic cleavage by urokinase is required for activation of hepatocyte growth factor/scatter factor". EMBO J. 11 (13): 4825–33. PMC 556958. PMID 1334458.
• Gloor S, Odink K, Guenther J, et al. (1987). "A glia-derived neurite promoting factor with protease inhibitory activity belongs to the protease nexins". Cell 47 (5): 687–93. doi:10.1016/0092-8674(86)90511-8. PMID 2877744.
• Sommer J, Gloor SM, Rovelli GF, et al. (1988). "cDNA sequence coding for a rat glia-derived nexin and its homology to members of the serpin superfamily". Biochemistry 26 (20): 6407–10. doi:10.1021/bi00394a016. PMID 3427015.
• Scott RW, Bergman BL, Bajpai A, et al. (1985). "Protease nexin. Properties and a modified purification procedure". J. Biol. Chem. 260 (11): 7029–34. PMID 3997857.
• Magnaldo T, Bernerd F, Darmon M (1995). "Galectin-7, a human 14-kDa S-lectin, specifically expressed in keratinocytes and sensitive to retinoic acid". Dev. Biol. 168 (2): 259–71. doi:10.1006/dbio.1995.1078. PMID 7729568.
• Donovan FM, Vaughan PJ, Cunningham DD (1994). "Regulation of protease nexin-1 target protease specificity by collagen type IV". J. Biol. Chem. 269 (25): 17199–205. PMID 8006028.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Nykjaer A, Conese M, Christensen EI, et al. (1997). "Recycling of the urokinase receptor upon internalization of the uPA:serpin complexes". EMBO J. 16 (10): 2610–20. doi:10.1093/emboj/16.10.2610. PMC 1169872. PMID 9184208.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Li Y, Lu YY (2002). "Applying a highly specific and reproducible cDNA RDA method to clone garlic up-regulated genes in human gastric cancer cells". World J. Gastroenterol. 8 (2): 213–6. PMID 11925594.
• Grabham PW, Monard D, Gallimore PH, Grand RJ (1991). "Modulation of Human Neurite Outgrowth by Serine Proteases: A Comparison of the Interaction of Thrombin and Prothrombin with Glia-Derived Nexin". The European Journal of Neuroscience 3 (7): 663–668. doi:10.1111/j.1460-9568.1991.tb00852.x. PMID 12106474.
• Crisp RJ, Knauer MF, Knauer DJ (2003). "Protease nexin 1 is a potent urinary plasminogen activator inhibitor in the presence of collagen type IV". J. Biol. Chem. 277 (49): 47285–91. doi:10.1074/jbc.M204813200. PMID 12356769.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Petrovic D, Milanez T, Kobal J, et al. (2003). "Prothrombotic gene polymorphisms and atherothrombotic cerebral infarction". Acta Neurol. Scand. 108 (2): 109–13. doi:10.1034/j.1600-0404.2003.00126.x. PMID 12859287.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim JA, Tran ND, Li Z, et al. (2006). "Brain endothelial hemostasis regulation by pericytes". J. Cereb. Blood Flow Metab. 26 (2): 209–17. doi:10.1038/sj.jcbfm.9600181. PMID 16015279.
• Navaneetham D, Jin L, Pandey P, et al. (2006). "Structural and mutational analyses of the molecular interactions between the catalytic domain of factor XIa and the Kunitz protease inhibitor domain of protease nexin 2". J. Biol. Chem. 280 (43): 36165–75. doi:10.1074/jbc.M504990200. PMID 16085935.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.

External links

• The MEROPS online database for peptidases and their inhibitors: I04.021
• SERPINE2 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)