Sabinene-hydrate synthase

sabinene-hydrate synthase
Identifiers
EC number	4.2.3.11
CAS number	166800-09-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a sabinene-hydrate synthase (EC 4.2.3.11) is an enzyme that catalyzes the chemical reaction

geranyl diphosphate + H₂O $\rightleftharpoons$ sabinene hydrate + diphosphate

Thus, the two substrates of this enzyme are geranyl diphosphate and H₂O, whereas its two products are sabinene hydrate and diphosphate.

This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. The systematic name of this enzyme class is geranyl-diphosphate diphosphate-lyase (cyclizing, sabinene-hydrate-forming). This enzyme is also called sabinene hydrate cyclase. This enzyme participates in monoterpenoid biosynthesis.

References

• Hallahan TW, Croteau R (1988). "Monoterpene biosynthesis: demonstration of a geranyl pyrophosphate:sabinene hydrate cyclase in soluble enzyme preparations from sweet marjoram (Majorana hortensis)". Arch. Biochem. Biophys. 264 (2): 618–31. doi:10.1016/0003-9861(88)90328-1. PMID 3401015.
• Hallahan TW, Croteau R (1989). "Monoterpene biosynthesis: mechanism and stereochemistry of the enzymatic cyclization of geranyl pyrophosphate to (+)-cis- and (+)-trans-sabinene hydrate". Arch. Biochem. Biophys. 269 (1): 313–26. doi:10.1016/0003-9861(89)90113-6. PMID 2916845.