Squalene—-hopanol cyclase

Squalene—-hopanol cyclase (EC 4.2.1.129, squalene—-hopene cyclase) is an enzyme with systematic name hopan-22-ol hydro-lyase.^[1]^[2] This enzyme catalyses the following chemical reaction

hopan-22-ol

\rightleftharpoons

squalene + H₂O

The enzyme produces the cyclization products hopene and hopanol.

References

↑ Hoshino, T., Nakano, S., Kondo, T., Sato, T. and Miyoshi, A. (2004). "Squalene-hopene cyclase: final deprotonation reaction, conformational analysis for the cyclization of (3R,S)-2,3-oxidosqualene and further evidence for the requirement of an isopropylidene moiety both for initiation of the polycyclization cascade and for the formation of the 5-membered E-ring". Org Biomol Chem 2: 1456–1470. doi:10.1039/b401172d. PMID 15136801.
↑ Sato, T., Kouda, M. and Hoshino, T. (2004). "Site-directed mutagenesis experiments on the putative deprotonation site of squalene-hopene cyclase from Alicyclobacillus acidocaldarius". Biosci. Biotechnol. Biochem. 68: 728–738. doi:10.1271/bbb.68.728. PMID 15056909.

External links

Squalene---hopanol cyclase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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