Terpinolene synthase

Terpinolene synthase (EC 4.2.3.113, ag9, PmeTPS2, LaLIMS_RR) is an enzyme with systematic name geranyl-diphosphate diphosphate-lyase (cyclizing, terpinolene-forming).^[1]^[2]^[3]^[4]^[5] This enzyme catalyses the following chemical reaction

geranyl diphosphate

\rightleftharpoons

terpinolene + diphosphate

This enzyme requires Mg²⁺.

References

↑ Croteau, R. and Satterwhite, D.M. (1989). "Biosynthesis of monoterpenes. Stereochemical implications of acyclic and monocyclic olefin formation by (+)- and (-)-pinene cyclases from sage". J. Biol. Chem. 264 (26): 15309–15315. PMID 2768265.
↑ Bohlmann, J., Phillips, M., Ramachandiran, V., Katoh, S. and Croteau, R. (1999). "cDNA cloning, characterization, and functional expression of four new monoterpene synthase members of the Tpsd gene family from grand fir (Abies grandis)". Arch. Biochem. Biophys. 368: 232–243. doi:10.1006/abbi.1999.1332. PMID 10441373.
↑ Faldt, J., Martin, D., Miller, B., Rawat, S. and Bohlmann, J. (2003). "Traumatic resin defense in Norway spruce (Picea abies): methyl jasmonate-induced terpene synthase gene expression, and cDNA cloning and functional characterization of (+)-3-carene synthase". Plant Mol. Biol. 51 (1): 119–133. doi:10.1023/A:1020714403780. PMID 12602896.
↑ Huber, D.P.W., Philippe, R.N., Godard, K.-A., Sturrock, R.N. and Bohlmann, J. (2005). "Characterization of four terpene synthase cDNAs from methyl jasmonate-induced Douglas-fir, Pseudotsuga menziesii". Phytochemistry 66: 1427–1439. doi:10.1016/j.phytochem.2005.04.030. PMID 15921711.
↑ Landmann, C., Fink, B., Festner, M., Dregus, M., Engel, K.H. and Schwab, W. (2007). "Cloning and functional characterization of three terpene synthases from lavender (Lavandula angustifolia)". Arch. Biochem. Biophys. 465 (2): 417–429. doi:10.1016/j.abb.2007.06.011. PMID 17662687.

External links

Terpinolene synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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