Tetrahymanol synthase

Tetrahymanol synthase (EC 4.2.1.123, squaleneatetrahymanol cyclase) is an enzyme with systematic name squalene hydro-lyase (tetrahymanol forming).^[1]^[2] This enzyme catalyses the following chemical reaction

tetrahymanol

\rightleftharpoons

squalene + H₂O

The reaction occurs in the reverse direction.

References

↑ Saar, J., Kader, J.C., Poralla, K. and Ourisson, G. (1991). "Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila". Biochim. Biophys. Acta 1075: 93–101. doi:10.1016/0304-4165(91)90080-z. PMID 1892870.
↑ Giner, J.L., Rocchetti, S., Neunlist, S., Rohmer, M. and Arigoni, D. (2005). "Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis". Chem. Commun. (Camb.): 3089–3091. doi:10.1039/b504300j. PMID 15959594.

External links

Tetrahymanol synthase at the US National Library of Medicine Medical Subject Headings (MeSH)

Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)

4.2.1: Hydro-Lyases	Carbonic anhydrase Fumarase Aconitase Enolase Alpha Enolase 2 Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase Methylglutaconyl-CoA hydratase Tryptophan synthase Cystathionine beta synthase Porphobilinogen synthase 3-Isopropylmalate dehydratase Urocanase Uroporphyrinogen III synthase Nitrile hydratase

4.2.2: Acting on polysaccharides	Hyaluronate lyase

4.2.3: Acting on phosphates	Threonine synthase

4.2.99: Other	Carboxymethyloxysuccinate lyase

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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