Thyroglobulin domain
| Thyroglobulin type-1 repeat | |||||||||
|---|---|---|---|---|---|---|---|---|---|
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Thyroglobulin type-1 domain | |||||||||
| Identifiers | |||||||||
| Symbol | Thyroglobulin_1 | ||||||||
| Pfam | PF00086 | ||||||||
| InterPro | IPR000716 | ||||||||
| PROSITE | PDOC00377 | ||||||||
| SCOP | 1icf | ||||||||
| SUPERFAMILY | 1icf | ||||||||
| CDD | cd00191 | ||||||||
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Thyroglobulin type-1 repeat is an evolutionary conserved protein domain. Thyroglobulin type 1 repeats are thought to be involved in the control of proteolytic degradation. The domain usually contains six conserved cysteines. These form three disulphide bridges. Cysteines 1 pairs with 2, 3 with 4 and 5 with 6.
Human proteins containing this domain
CD74; IGFBP-4; IGFBP1; IGFBP2; IGFBP3; IGFBP4; IGFBP5; IGFBP6; NID1; NID2; SMOC1; SMOC2; SPOCK1; SPOCK2; SPOCK3; TACSTD1; TACSTD2; TG;
References
- Gunčar, G.; Pungerčič, G.; Klemenčič, I.; Turk, V.; Turk, D. A. (1999). "Crystal structure of MHC class II-associated p41 Ii fragment bound to cathepsin L reveals the structural basis for differentiation between cathepsins L and S". The EMBO Journal 18 (4): 793–803. doi:10.1093/emboj/18.4.793. PMC 1171172. PMID 10022822.
- Molina, F.; Bouanani, M.; Pau, B.; Granier, C. (1996). "Characterization of the type-1 repeat from thyroglobulin, a cysteine-rich module found in proteins from different families". European Journal of Biochemistry / FEBS 240 (1): 125–133. doi:10.1111/j.1432-1033.1996.0125h.x. PMID 8797845.
This article incorporates text from the public domain Pfam and InterPro IPR000519
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