Vitiligo

Vitiligo

Non-segmental vitiligo of the hand.
Classification and external resources
Pronunciation /ˌvɪtᵻˈlaɪɡoʊ/
Specialty Dermatology
ICD-10 L80
ICD-9-CM 709.01
OMIM 193200
DiseasesDB 13965
MedlinePlus 000831
eMedicine derm/453
Patient UK Vitiligo
MeSH D014820

Vitiligo is a chronic skin condition characterized by portions of the skin losing their pigment. It occurs when skin pigment cells die or are unable to function. Aside from cases of contact with certain chemicals,[1] the cause of vitiligo is unknown. Research suggests vitiligo may arise from autoimmune, genetic, oxidative stress, neural, or viral causes.[2] Vitiligo is typically classified into two main categories: segmental and non-segmental vitiligo. Half of those affected show the disorder before age 20, though most develop it before age 40. [3]

The global incidence of vitiligo is less than 1%,[4] with some populations averaging 2–3% and rarely as high as 16%.[5] Autoimmune diseases such as Addison's disease, Hashimoto's thyroiditis, and type 1 diabetes mellitus tend to occur more often in people who have vitiligo. There is no known cure for vitiligo but many treatment options are available including topical steroids, calcineurin inhibitors, and phototherapy.

Classification

Classification attempts to quantify vitiligo have been analyzed as being somewhat inconsistent,[6] while recent consensus have agreed to a system of segmental vitiligo (SV) and non-segmental vitiligo (NSV). NSV is the most common type of vitiligo.[7]

Non-segmental

In non-segmental vitiligo (NSV), there is usually some form of symmetry in the location of the patches of depigmentation. New patches also appear over time and can be generalized over large portions of the body or localized to a particular area. Vitiligo where little pigmented skin remains is referred to as vitiligo universalis. NSV can come about at any age (unlike segmental vitiligo, which is far more prevalent in teenage years).[8]

Classes of non-segmental vitiligo include the following:

Segmental

Segmental vitiligo (SV) differs in appearance, cause and prevalence from associated illnesses. Its treatment is different from that of NSV. It tends to affect areas of skin that are associated with dorsal roots from the spinal cord and is most often unilateral.[7][10] It spreads much more rapidly than NSV and, without treatment, it is much more stable/static in course and its association with autoimmune diseases appears to be weaker than that of generalized vitiligo.[10] SV is a very treatable condition that responds to topical treatment.[8]

Signs and symptoms

Vitiligo on lighter skin
Vitiligo on darker skin

The only sign of vitiligo is the presence of pale patchy areas of depigmented skin which tend to occur on the extremities.[11][12] The patches are initially small, but often grow and change shape.[2][11] When skin lesions occur, they are most prominent on the face, hands and wrists.[11][12] The loss of skin pigmentation is particularly noticeable around body orifices, such as the mouth, eyes, nostrils, genitalia and umbilicus.[11][12] Some lesions have increased skin pigment around the edges.[8] Patients who are stigmatized for their condition may experience depression and similar mood disorders.[13]

Causes

Although multiple hypotheses have been suggested as potential triggers that cause vitiligo, studies strongly imply that changes in the immune system are responsible for the condition.[7][14] Vitiligo has been proposed to be a multifactorial disease with genetic susceptibility and environmental factors both thought to play a role.[7]

The TYR gene encodes the protein tyrosinase, which is not a component of the immune system, but is an enzyme of the melanocyte that catalyzes melanin biosynthesis, and a major autoantigen in generalized vitiligo.[7] Some state the sunburns can cause the disease but there is not good evidence to support this.[15]

Immune

Variations in genes that are part of the immune system or part of melanocytes have both been associated with vitiligo.[7] It is also thought to be caused by the immune system attacking and destroying the melanocytes of the skin.[16] A genomewide association study found approximately 36 independent susceptibility loci for generalized vitiligo.[17]

Autoimmune associations

Vitiligo is sometimes associated with autoimmune and inflammatory diseases such as Hashimoto's thyroiditis, scleroderma, rheumatoid arthritis, type 1 diabetes mellitus, psoriasis, Addison's disease, pernicious anemia, alopecia areata, and systemic lupus erythematosus.[7]

Among the inflammatory products of NALP1 are caspase 1 and caspase 7, which activate the inflammatory cytokine interleukin-1β. Interleukin-1β is expressed at high levels in patients with vitiligo. In one of the mutations, the amino acid leucine in the NALP1 protein was replaced by histidine (Leu155->His). The original protein and sequence is highly conserved in evolution, and is found in humans, chimpanzee, rhesus monkey, and the bush baby. Addison's disease (typically an autoimmune destruction of the adrenal glands) may also be seen in individuals with vitiligo.[18][19]

Diagnosis

UV photograph of a hand with vitiligo
UV photograph of a foot with vitiligo

An ultraviolet light can be used in the early phase of this disease for identification and to determine effectiveness of treatment. Skin with vitiligo, when exposed to a blacklight, will glow blue. In contrast, healthy skin will have no reaction.

Differential diagnosis

Conditions with similar symptoms include the following:

Treatment

There is no cure for vitiligo but several treatment options are available.[7] The best evidence is for applied steroids and the combination of ultraviolet light in combination with creams.[20] Due to the higher risks of skin cancer, the United Kingdom's National Health Service suggests phototherapy only be used if primary treatments are ineffective.[21] Lesions located on the hands, feet, and joints are the most difficult to repigment; those on the face are easiest to return to the natural skin color.[7]

Immune mediators

Topical preparations of immune suppressing medications including glucocorticoids (such as 0.05% clobetasol or 0.10% betamethasone) and calcineurin inhibitors (such as tacrolimus or pimecrolimus) are considered to be first-line vitiligo treatments.[7]

Phototherapy

Phototherapy is considered a second-line treatment for vitiligo.[7] Exposing the skin to light from UVB lamps is the most common treatment for vitiligo. The treatments can be done at home with an UVB lamp or in a clinic. The exposure time is managed so that the skin doesn't suffer overexposure. Treatment can take a few weeks if the spots are on the neck and face and if they existed not more than 3 years. If the spots are on the hands and legs and have been there more than 3 years, it can take a few months. Phototherapy sessions are done 2–3 times a week. Spots on a large area of the body may require full body treatment in a clinic or hospital. UVB broadband and narrowband lamps can be used,[22][23] but narrowband ultraviolet picked around 311 nm is the choice. It has been constitutively reported that combination of UVB phototherapy with other topical treatments improves repigmentation.

Ultraviolet light (UVA) treatments are normally carried out in a hospital clinic. Psoralen and ultraviolet A light (PUVA) treatment involves taking a drug that increases the skin's sensitivity to ultraviolet light, then exposing the skin to high doses of UVA light. Treatment is required twice a week for 6–12 months or longer. Because of the high doses of UVA and psoralen, PUVA may cause side effects such as sunburn-type reactions or skin freckling.[21]

Narrowband ultraviolet B (NBUVB) phototherapy lacks the side-effects caused by psoralens and is as effective as PUVA.[7] As with PUVA, treatment is carried out twice weekly in a clinic or every day at home, and there is no need to use psoralen.[21]

Skin camouflage

In mild cases, vitiligo patches can be hidden with makeup or other cosmetic camouflage solutions. If the affected person is pale-skinned, the patches can be made less visible by avoiding tanning of unaffected skin.[9]

De-pigmenting

Most vitiligo is idiopathic; however, in cases where it is triggered by skin bleaching or other substances, it is said to be chemical after being treated with bleaching agents. In cases of extensive vitiligo the option to de-pigment the unaffected skin with topical drugs like monobenzone, mequinol, or hydroquinone may be considered to render the skin an even colour. The removal of all the skin pigment with monobenzone is permanent and vigorous. Sun-safety must be adhered to for life to avoid severe sun burn and melanomas. Depigmentation takes about a year to complete.[21]

History

Descriptions of a disease believed to be vitiligo date back to a passage in the medical text Ebers Papyrus circa 1500 BC in ancient Egypt. Mentions of whitening of the skin was also present circa 1400 BC in sacred Indian texts such as Atharvaveda as well as Shinto prayers in East Asia circa 1200 BC. The Hebrew word "Zora'at" from the Old Testament book of Leviticus[24] dating to 1280 BCE[25] (or 1312 BCE[26]) described a group of skin disease associated with white spots, and a subsequent translation to Greek led to continued conflation of those with vitiligo with leprosy and spiritual uncleanliness.[24] Medical sources in the ancient world such as Hippocrates often did not differentiate between vitiligo and leprosy, often grouping these diseases together. In Arabic literature, the word "alabras" has been associated with vitiligo, with this word found in the Koran. The name "vitiligo" was first used by the Roman physician Aulus Cornelius Celsus in his classic medical text De Medicina.[24]

Etymology

The etymology of the term "vitiligo" is believed to be derived from "vitium", meaning "defect" or "blemish".[24]

Notable cases

Michael Jackson was diagnosed with vitiligo universalis.

Research

Afamelanotide is in phase II and III clinical trials for vitiligo and other skin diseases.[34]

A medication for rheumatoid arthritis, tofacitinib, has been tested for the treatment of vitiligo.[35]

In October 1992, a scientific report was published of successfully transplanting melanocytes to vitiligo affected areas, effectively repigmenting the region.[36] The procedure involved taking a thin layer of pigmented skin from the patient's gluteal region. Melanocytes were then separated out to a cellular suspension that was expanded in culture. The area to be treated was then denuded with a dermabrader and the melanocytes graft applied. Between 70 and 85 percent of patients experienced nearly complete repigmentation of their skin. The longevity of the repigmentation differed from person to person.[37] By now, a number of transplantation techniques has been developed, including transplantation of melanocyte precursors derived from hair follicles. Transplantation procedures are frequently used to treat segmental vitiligo which is poorly responsive to other types of treatment. In non-segmental vitiligo, success is achieved when treating patches that are not expanding (so called stable vitiligo).

See also

References

  1. ↑ Rietschel, Robert L.; Fowler, Joseph F., Jr. (2001). Fisher's Contact Dermatitis (5th ed.). Philadelphia: Lippincott Williams & Wilkins. pp. 571–577. ISBN 0-7817-2252-7.
  2. 1 2 Halder, RM; Chappell, JL (2009). "Vitiligo update". Seminars in cutaneous medicine and surgery 28 (2): 86–92. doi:10.1016/j.sder.2009.04.008. PMID 19608058.
  3. ↑ Tamparo, Carol. Diseases of the Human Body (Fifth Edition ed.). Philadelphia, PA. p. 196. ISBN 978-0-8036-2505-1.
  4. ↑ Nath SK, Majumder PP, Nordlund JJ (1994). "Genetic epidemiology of vitiligo: multilocus recessivity cross-validated". American Journal of Human Genetics 55 (5): 981–90. PMC 1918341. PMID 7977362.
  5. ↑ Krüger C, Schallreuter KU (October 2012). "A review of the worldwide prevalence of vitiligo in children/adolescents and adults". Int J Dermatol 51 (10): 1206–12. doi:10.1111/j.1365-4632.2011.05377.x. PMID 22458952.
  6. ↑ Vitiligo by Mauro Picardo and Alain Taïeb (Dec 17, 2009), Introduction section.
  7. 1 2 3 4 5 6 7 8 9 10 11 12 Ezzedine K, Eleftheriadou V, Whitton M, van Geel N (January 2015). "Vitiligo". Lancet. S0140-6736 (14): 60763–7. doi:10.1016/S0140-6736(14)60763-7. PMID 25596811.
  8. 1 2 3 Huggins RH, Schwartz RA, Janniger CK (2005). "Vitiligo" (PDF). Acta Dermatovenerologica Alpina, Panonica, et Adriatica 14 (4): 137–42, 144–5. PMID 16435042.
  9. 1 2 3 4 5 6 7 8 9 10 Halder, R. M.; et al. (2007). "Vitiligo". In Wolff, K.; et al. Fitzpatrick's Dermatology in General Medicine (7th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-146690-5.
  10. 1 2 van Geel N, Mollet I, Brochez L, Dutré M, De Schepper S, Verhaeghe E, Lambert J, Speeckaert R (February 2012). "New insights in segmental vitiligo: case report and review of theories". British Journal of Dermatology 166 (2): 240–6. doi:10.1111/j.1365-2133.2011.10650.x. PMID 21936857.
  11. 1 2 3 4 National Institute of Arthritis and Musculoskeletal and Skin Diseases (March 2007). "What Is Vitiligo? Fast Facts: An Easy-to-Read Series of Publications for the Public Additional". Retrieved 2010-07-18.
  12. 1 2 3 Halder RM, et al. (2007). "72. Vitiligo". In Wolff K, Freedberg IM, Fitzpatrick TB (eds). Fitzpatrick's dermatology in general medicine (7th ed.). New York: McGraw-Hill Professional. ISBN 978-0-07-146690-5. OCLC 154751587.
  13. ↑ Picardi A, Pasquini P, Cattaruzza MS, Gaetano P, Melchi CF, Baliva G, Camaioni D, Tiago A, Abeni D, Biondi M (2003). "Stressful life events, social support, attachment security and alexithymia in vitiligo. A case-control study". Psychotherapy and Psychosomatics 72 (3): 150–8. doi:10.1159/000069731. PMID 12707482.
  14. ↑ Ongenae, Katia; Van Geel, Nanny; Naeyaert, Jean-Marie (Apr 2003). "Evidence for an Autoimmune Pathogenesis of Vitiligo". Pigment Cell Research 16 (2): 90–100. doi:10.1034/j.1600-0749.2003.00023.x.
  15. ↑ "Questions and Answers about Vitiligo". June 2014. Retrieved 4 October 2015.
  16. ↑ Staff, Mayo Clinic (May 15, 2014). "Vitiligo Causes". Mayoclinic. Retrieved April 22, 2015.
  17. ↑ Spritz, Richard A. (May 2013). "Modern vitiligo genetics sheds new light on an ancient disease". The Journal of Dermatology 40 (5): 310–318. doi:10.1111/1346-8138.12147.
  18. ↑ Gregersen PK (2007). "Modern genetics, ancient defenses, and potential therapies". The New England Journal of Medicine 356 (12): 1263–6. doi:10.1056/NEJMe078017. PMID 17377166.
  19. ↑ Jin Y, Mailloux CM, Gowan K, et al. (2007). "NALP1 in vitiligo-associated multiple autoimmune disease". The New England Journal of Medicine 356 (12): 1216–25. doi:10.1056/NEJMoa061592. PMID 17377159.
  20. ↑ Whitton, ME; Ashcroft, DM; González, U (Oct 2008). "Therapeutic interventions for vitiligo.". Journal of the American Academy of Dermatology 59 (4): 713–7. doi:10.1016/j.jaad.2008.06.023. PMID 18793940.
  21. 1 2 3 4 Anon. "Vitiligo -Treatment". Patient UK. NHS. Retrieved 2013-06-03.
  22. ↑ Scherschun, L; Kim, JJ; Lim, HW (2001). "Narrow-band ultraviolet B is a useful and well-tolerated treatment for vitiligo". Journal of the American Academy of Dermatology 44 (6): 999–1003. doi:10.1067/mjd.2001.114752. PMID 11369913.
  23. ↑ Don, Philip; Iuga, Aurel; Dacko, Anne; Hardick, Kathleen (2006). "Treatment of vitiligo with broadband ultraviolet B and vitamins". International Journal of Dermatology 45 (1): 63–5. doi:10.1111/j.1365-4632.2005.02447.x. PMID 16426381.
  24. 1 2 3 4 Taieb, edited by Mauro Picardo, Alain (2009). Vitiligo (Online-Ausg. ed.). Berlin: Springer. ISBN 978-3-540-69360-4.
  25. ↑ Kurzweil, Arthur (2008). The Torah For Dummies (PDF). For Dummies. p. 11. ISBN 978-0-470-28306-6. Retrieved 2010-08-19.
  26. ↑ History Crash Course #36: Timeline: From Abraham to Destruction of the Temple, by Rabbi Ken Spiro, Aish.com. Retrieved 2010-08-19.
  27. ↑ Duke, Alan (7 May 2013). "Autopsy reveals Michael Jackson's secrets". CNN Entertainment (CNN). Retrieved 7 May 2013. The autopsy apparently confirmed what Jackson told people who questioned why his skin tone became lighter in the 1980s. Jackson had 'vitiligo, a skin pigmentation disease,' [LA coroner Dr. Christopher] Rogers said. 'So, some areas of the skin appear light and others appear dark.'
  28. ↑ Taylor, Victoria (8 May 2014). "‘America’s Next Top Model’ contestant hasn't let rare skin condition hold her back". New York Daily News. Retrieved 9 May 2014.
  29. ↑ "New Delhi: Justice Sathasivam sworn in as chief justice of India". mangalorean.com. July 19, 2013
  30. ↑ Gonzalez, Edgar (2011). "Can Rubio beat Chavez?". My Boxing Fans.
  31. ↑ ESPN.com: Karl Dunbar knows the winner within
  32. ↑ "HuffPost Teen's '18 Under 18' Of 2012! (PHOTOS)". Huffington Post. 31 December 2012.
  33. ↑ "Daniel Bryan (July 30, 2011). "Tweet Number 97214858474422272". Twitter.". 31 October 2014.
  34. ↑ Fabrikant J; et al. (Jul 2013). "A review and update on melanocyte stimulating hormone therapy: afamelanotide". J Drugs Dermatol 12 (7): 775–9. PMID 23884489.
  35. ↑ "For vitiligo patient, arthritis drug restores skin color".
  36. ↑ Olsson MJ, Juhlin L (1992). "Melanocyte transplantation in vitiligo". Lancet 340 (8825): 981. doi:10.1016/0140-6736(92)92875-G. PMID 1357390.
  37. ↑ Olsson MJ, Juhlin L (2002). "Long-term follow-up of leucoderma patients treated with transplants of autologous cultured melanocytes, ultrathin epidermal sheets and basal cell layer suspension". The British Journal of Dermatology 147 (5): 893–904. doi:10.1046/j.1365-2133.2002.04837.x. PMID 12410698.

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