Trimerelysin I

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Trimerelysin I (EC 3.4.24.52, Trimeresurus metalloendopeptidase I, hemorrhagic proteinase HR1A, hemorrhagic metalloproteinase HR1A, metalloproteinase HR1A) is an enzyme.^[1]^[2]^[3] This enzyme catalyses the following chemical reaction

Cleavage of only two bonds His¹⁰-Leu and Ala¹⁴-Leu in the insulin B chain

This endopeptidase is present in the venom of the habu snake (Trimeresurus flavoviridis).

References

↑ Omori-Satoh, T. and Sadahiro, S. (1979). "Resolution of the major hemorrhagic component of Trimeresurus flavoviridis venom into two parts". Biochim. Biophys. Acta 580: 392–404. doi:10.1016/0005-2795(79)90151-x. PMID 518906.
↑ Yamakawa, Y. and Omori-Satoh, T. (1988). "The sites of cleavage in oxidized insulin-B chain by a hemorrhagic protease derived from the venom of the habu (Trimeresurus flavoviridis)". Toxicon 26: 227–231. doi:10.1016/0041-0101(88)90178-x. PMID 3284004.
↑ Takeya, H., Oda, K., Miyata, T., Omori-Satoh, T. and Iwanaga, S. (1990). "The complete amino acid sequence of the high molecular mass hemorrhagic protein HR1B isolated from the venom of Trimeresurus flavoviridis". J. Biol. Chem. 265: 16068–16073. PMID 2398046.

External links

Trimerelysin I at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: metalloendopeptidases (EC 3.4.24)

ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13

Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28

Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

Enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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