Ulp1 peptidase

Ulp1 peptidase (EC 3.4.22.68, Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme.^[1]^[2]^[3]^[4]^[5]^[6] This enzyme catalyses the following chemical reaction

Hydrolysis of the alpha-linked peptide bond in the sequence Gly-Gly-!Ala-Thr-Tyr at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptide, Smt3

The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human.

References

↑ Lima, C.D. (2004). "Ulp1 endopeptidase". In Barrett, A.J., Rawlings, N.D. and Woessner, J.F. Handbook of Proteolytic Enzymes (2nd ed.). London: Elsevier. pp. 1340–1344.
↑ Li, S.-J. and Hochstrasser, M. (1999). "A new protease required for cell-cycle progression in yeast". Nature 398 (6724): 246–251. doi:10.1038/18457. PMID 10094048.
↑ Taylor, D.L., Ho, J.C., Oliver, A. and Watts, F.Z. (2002). "Cell-cycle-dependent localisation of Ulp1, a Schizosaccharomyces pombe Pmt3 (SUMO)-specific protease". J. Cell Sci. 115 (Pt 6): 1113–1122. PMID 11884512.
↑ Li, S.-J. and Hochstrasser, M. (2003). "The Ulp1 SUMO isopeptidase: distinct domains required for viability, nuclear envelope localization, and substrate specificity". J. Cell Biol. 160 (7): 1069–1081. doi:10.1083/jcb.200212052. PMID 12654900.
↑ Ihara, M., Koyama, H., Uchimura, Y., Saitoh, H. and Kikuchi, A. (2007). "Noncovalent binding of small ubiquitin-related modifier (SUMO) protease to SUMO is necessary for enzymatic activities and cell growth". J. Biol. Chem. 282: 16465–16475. doi:10.1074/jbc.M610723200. PMID 17428805.
↑ Mukhopadhyay, D. and Dasso, M. (2007). "Modification in reverse: the SUMO proteases". Trends Biochem. Sci. 32 (6): 286–295. doi:10.1016/j.tibs.2007.05.002. PMID 17499995.

External links

Ulp1 peptidase at the US National Library of Medicine Medical Subject Headings (MeSH)

Proteases: cysteine proteases (EC 3.4.22)

Caspase	Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase 13 Caspase 14

Fruit-derived	Papain Ficain Bromelain Actinidain

Calpain	CAPN1 CAPN2 CAPN3 CAPN5 CAPN6 CAPN7 CAPN8 CAPN9 CAPN10 CAPN11 CAPN12 CAPN13 CAPN14 CAPNS1 CAPNS2

Cathepsin	B C F H K L1/L2 O S W Z

Other	Clostripain Cancer procoagulant Separase Autophagin Cruzipain

Proteins: enzymes

Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis Enzyme kinetics Lineweaver–Burk plot Michaelis–Menten kinetics

Regulation	Allosteric regulation Cooperativity Enzyme inhibitor

Classification	EC number Enzyme superfamily Enzyme family List of enzymes

Types	EC1 Oxidoreductases(list) EC2 Transferases(list) EC3 Hydrolases(list) EC4 Lyases(list) EC5 Isomerases(list) EC6 Ligases(list)

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