Ambuphylline

Ambuphylline
Names

IUPAC name 1,3-dimethyl-7H-purine-2,6-dione : 2-amino-2-methylpropan-1-ol
Other names Theophylline aminoisobutanol, bufylline
Identifiers
CAS Number	5634-34-4^Y
ChEMBL	ChEMBL2104089^N
ChemSpider	20536^Y
Jmol interactive 3D	Image
KEGG	D02884^Y
PubChem	21850
UNII	VOU5V0B772^Y
InChI InChI=1S/C7H8N4O2.C4H11NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-4(2,5)3-6/h3H,1-2H3,(H,8,9);6H,3,5H2,1-2H3^Y Key: SEIRRUDMPNNSCY-UHFFFAOYSA-N^Y InChI=1/C7H8N4O2.C4H11NO/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;1-4(2,5)3-6/h3H,1-2H3,(H,8,9);6H,3,5H2,1-2H3 Key: SEIRRUDMPNNSCY-UHFFFAOYAX
SMILES O=C2N(c1ncnc1C(=O)N2C)C.OCC(N)(C)C
Properties
Chemical formula	C₁₁H₁₉N₅O₃
Molar mass	269.30 g/mol
Appearance	Crystalline, slightly yellowish white powder
Melting point	254 to 256 °C (489 to 493 °F; 527 to 529 K)
Solubility in water	Freely soluble.
Pharmacology
ATC code	R03DA10
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
N verify (what is ^YN ?)
Infobox references

Ambuphylline (or bufylline) is a combination of theophylline and aminoisobutanol used as a bronchodilator.^[1] It also acts and may be used as a diuretic.^[2]

References

↑ Smith, J. R.; Jensen, J. (1946). "The effect of theophylline aminoisobutanol in the failing experimental heart". The Journal of laboratory and clinical medicine 31: 455–457. PMID 21022557.
↑ http://www.mondofacto.com/facts/dictionary?query=ambuphylline&action=look+it+up

Drugs for obstructive airway diseases: asthma/COPD (R03)

Adrenergics, inhalants

Short-acting β₂ agonists	Bitolterol Carbuterol Fenoterol Pirbuterol Procaterol Reproterol Rimiterol Salbutamol (albuterol)^#/Levosalbutamol (levalbuterol) Terbutaline Tulobuterol

Long-acting β₂ agonists (LABA)	Bambuterol Clenbuterol Formoterol/Arformoterol Salmeterol Salmefamol

Ultra-long-acting β₂ agonists	Indacaterol Olodaterol Vilanterol

Other	Epinephrine^# Hexoprenaline Isoprenaline (isoproterenol) Orciprenaline (metaproterenol)

Glucocorticoids

Anticholinergics/
muscarinic antagonist

Mast cell stabilizers

Xanthines

Eicosanoid inhibition

Leukotriene antagonists	Montelukast Pranlukast Zafirlukast

Arachidonate 5-lipoxygenase inhibitors	Baicalein^§ Caffeic acid^§ Curcumin^§ Hyperforin^§ Meclofenamate sodium^§ St John's wort^§ Zileuton

Thromboxane receptor antagonists	Ramatroban Seratrodast

Non-xanthine PDE4 inhibitors	Ibudilast Roflumilast

Others/unknown

Combination products

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

This article is issued from Wikipedia - version of the Monday, November 30, 2015. The text is available under the Creative Commons Attribution/Share Alike but additional terms may apply for the media files.