Pranlukast

Pranlukast

Systematic (IUPAC) name
N-[4-oxo-2-(1H-tetrazol-5-yl)-4H-chromen-8-yl]-4-(4-phenylbutoxy)benzamide
Clinical data
Trade names	Onon (オノン)
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Pharmacokinetic data
Metabolism	Hepatic (mainly CYP3A4)[1]
Biological half-life	1.5 hours[1]
Identifiers
CAS Number	103177-37-3
ATC code	R03DC02 (WHO)
PubChem	CID 4887
IUPHAR/BPS	3634
DrugBank	DB01411
ChemSpider	4718
UNII	TB8Z891092
ChEMBL	CHEMBL21333
Chemical data
Formula	C27H23N5O4
Molar mass	481.503 g/mol
SMILES O=C(c2ccc(OCCCCc1ccccc1)cc2)Nc5cccc3c5O/C(=C\C3=O)c4nnnn4
InChI InChI=1S/C27H23N5O4/c33-23-17-24(26-29-31-32-30-26)36-25-21(23)10-6-11-22(25)28-27(34)19-12-14-20(15-13-19)35-16-5-4-9-18-7-2-1-3-8-18/h1-3,6-8,10-15,17H,4-5,9,16H2,(H,28,34)(H,29,30,31,32) Key:NBQKINXMPLXUET-UHFFFAOYSA-N
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Pranlukast (brand name Onon, オノン) is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan.

Medications of this class, which go under a variety of names according to whether one looks at the American, British or European system of nomenclature, have as their primary function the antagonism of bronchospasm caused, principally in asthmatics, by an allergic reaction to accidentally or inadvertently encountered allergens.

Medications of this group are normally used as an adjunct to the standard therapy of inhaled steroids with inhaled long- and/or short-acting beta-agonists. There are several similar medications in the group; all appear to be equally effective.

References

1. Nakade S, Ueda S, Ohno T, Nakayama K, Miyata Y, Yukawa E, Higuchi S (2006). "Population pharmacokinetics of pranlukast hydrate dry syrup in children with allergic rhinitis and bronchial asthma.". Drug Metab Pharmacokinet 21 (2): 133–9. doi:10.2133/dmpk.21.133. PMID 16702733.