Leukotriene-C4 hydrolase

Leukotriene-C4 hydrolase
Identifiers
EC number	3.4.19.14
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Leukotriene-C4 hydrolase (EC 3.4.19.14, gamma-glutamyl leukotrienase, GGT5) is an enzyme.^[1][2][3][4] This enzyme catalyses the following chemical reaction

leukotriene C4 + H₂O $\rightleftharpoons$ leukotriene D4 + L-glutamate

The mouse enzyme is specific for leukotriene C4.

References

1. Carter, B.Z., Wiseman, A.L., Orkiszewski, R., Ballard, K.D., Ou, C.N. and Lieberman, M.W. (1997). "Metabolism of leukotriene C₄ in γ-glutamyl transpeptidase-deficient mice". J. Biol. Chem. 272: 12305–12310. doi:10.1074/jbc.272.19.12305. PMID 9139674.
2. Shi, Z.Z., Han, B., Habib, G.M., Matzuk, M.M. and Lieberman, M.W. (2001). "Disruption of γ-glutamyl leukotrienase results in disruption of leukotriene D₄ synthesis in vivo and attenuation of the acute inflammatory response". Mol. Cell. Biol. 21: 5389–5395. doi:10.1128/mcb.21.16.5389-5395.2001. PMID 11463821.
3. Han, B., Luo, G., Shi, Z.Z., Barrios, R., Atwood, D., Liu, W., Habib, G.M., Sifers, R.N., Corry, D.B. and Lieberman, M.W. (2002). "γ-glutamyl leukotrienase, a novel endothelial membrane protein, is specifically responsible for leukotriene D₄ formation in vivo". Am J Pathol 161: 481–490. doi:10.1016/s0002-9440(10)64204-6. PMID 12163373.
4. Wickham, S., West, M.B., Cook, P.F. and Hanigan, M.H. (2011). "Gamma-glutamyl compounds: substrate specificity of γ-glutamyl transpeptidase enzymes". Anal. Biochem. 414: 208–214. doi:10.1016/j.ab.2011.03.026. PMID 21447318.

External links

• Leukotriene-C4 hydrolase at the US National Library of Medicine Medical Subject Headings (MeSH)