Doxofylline

Doxofylline

Systematic (IUPAC) name
7-(1,3-Dioxolan-2-ylmethyl)-1,3-dimethylpurine-2,6-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Routes of administration	Oral
Legal status
Legal status	℞ (Prescription only)
Identifiers
CAS Number	69975-86-6
ATC code	R03DA11 (WHO)
PubChem	CID 50942
DrugBank	DB09273
ChemSpider	46175
UNII	MPM23GMO7Z
KEGG	D03898
Chemical data
Formula	C11H14N4O4
Molar mass	266.25 g/mol
SMILES CN1C2=C(C(=O)N(C1=O)C)N(C=N2)CC3OCCO3
InChI InChI=1S/C11H14N4O4/c1-13-9-8(10(16)14(2)11(13)17)15(6-12-9)5-7-18-3-4-19-7/h6-7H,3-5H2,1-2H3 Key:HWXIGFIVGWUZAO-UHFFFAOYSA-N
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Doxofylline (INN, also known as doxophylline) is a xanthine derivative drug used in the treatment of asthma.^[1]

It has antitussive and bronchodilator^[2] effects, and acts as a phosphodiesterase inhibitor.^[3]

In animal and human studies, it has shown similar efficacy to theophylline but with significantly fewer side effects.^[4]

Unlike other xanthines, doxofylline lacks any significant affinity for adenosine receptors and does not produce stimulant effects. This suggests that its antiasthmatic effects are mediated by another mechanism, perhaps its actions on phosphodiesterase.^[1]

References

1. Cirillo R, Barone D, Franzone JS (1988). "Doxofylline, an antiasthmatic drug lacking affinity for adenosine receptors". Arch Int Pharmacodyn Ther 295: 221–37. PMID 3245738.
2. Poggi R, Brandolese R, Bernasconi M, Manzin E, Rossi A (October 1989). "Doxofylline and respiratory mechanics. Short-term effects in mechanically ventilated patients with airflow obstruction and respiratory failure". Chest 96 (4): 772–8. doi:10.1378/chest.96.4.772. PMID 2791671.
3. Dini FL, Cogo R (2001). "Doxofylline: a new generation xanthine bronchodilator devoid of major cardiovascular adverse effects". Curr Med Res Opin 16 (4): 258–68. doi:10.1185/030079901750120196. PMID 11268710.
4. Sankar J, Lodha R, Kabra SK (March 2008). "Doxofylline: The next generation methylxanthine". Indian J Pediatr 75 (3): 251–4. doi:10.1007/s12098-008-0054-1. PMID 18376093.

Further reading

• Shukla, Dali; Chakraborty, Subhashis; Singh, Sanjay; Mishra, Brahmeshwar (2009). "Doxofylline: A promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease". Expert Opinion on Pharmacotherapy 10 (14): 2343. doi:10.1517/14656560903200667. PMID 19678793.