Udenafil

Udenafil
Systematic (IUPAC) name

3-(1-methyl-7-oxo-3-propyl-4,7-dihydro-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-N-[2-(1-methylpyrrolidin-2-yl)ethyl]-4-propoxybenzenesulfonamide
Pharmacokinetic data
Biological half-life	7.3–12.1 hours
Identifiers
CAS Number	268203-93-6^N
ATC code	G04BE11 (WHO)
PubChem	CID 6918523
DrugBank	DB06267^Y
ChemSpider	5293720^Y
UNII	L5IB4XLY36^Y
KEGG	D10027^N
Chemical data
Formula	C₂₅H₃₆N₆O₄S
Molar mass	516.657 g/mol
SMILES O=C2\N=C(/Nc1c(nn(c12)C)CCC)c3cc(ccc3OCCC)S(=O)(=O)NCCC4N(C)CCC4
InChI InChI=1S/C25H36N6O4S/c1-5-8-20-22-23(31(4)29-20)25(32)28-24(27-22)19-16-18(10-11-21(19)35-15-6-2)36(33,34)26-13-12-17-9-7-14-30(17)3/h10-11,16-17,26H,5-9,12-15H2,1-4H3,(H,27,28,32)^Y Key:IYFNEFQTYQPVOC-UHFFFAOYSA-N^Y
^NY (what is this?) (verify)

The drug udenafil, marketed under the trade name Zydena, is within the PDE5-inhibitor class (which also includes avanafil, sildenafil, tadalafil, and vardenafil). Used, like other PDE5 inhibitors, to treat erectile dysfunction, undenafil was developed by Dong-A Pharmaceutical.^[1] With action of fairly rapid onset (peak plasma concentration after 1 to 1.5 hours) yet long duration (plasma half life of 11 to 13 hours), udenafil's pharmacokinetics allows once-daily dosage (in addition to on-demand use).^[2] Typical doses are 100 and 200 mg. Udenafil is available in Korea, Russia, and the Philippines;^[3] in the United States, it has not been approved by the U.S. Food and Drug Administration.

References

↑ Zydena (udenafil) product-information page. Dong-A Pharmaceutical. Retrieved on April 13, 2009.
↑ "Udenafil: Efficacy and tolerability in the management of erectile dysfunction".
↑ [http://www.drugs.com/international/zydena.html "Zydena", Drugs.com

Drugs for erectile dysfunction (G04BE) and premature ejaculation

For erectile dysfunction

Prostaglandins (E)	Alprostadil

PDE5 inhibitors	Avanafil Sildenafil Tadalafil Udenafil Vardenafil

Alpha blockers	Moxisylyte Phentolamine Yohimbine

Dopamine agonists	Apomorphine

Melanocortin agonists	Bremelanotide Melanotan II PL-6983

Others	Afrodor (acecarbromal, quebracho, vitamin E) Papaverine

For premature ejaculation

SSRIs	Dapoxetine

Oxytocin antagonists	Epelsiban

DRA/DRIs	Amphetamine Methamphetamine Methylphenidate

See also: Sexual dysfunction pharmacotherapies

PDE inhibitors

PDE1	MMPX SCH-51866 Vinpocetine

PDE2	BAY 60-7550 EHNA Oxindole PDP

PDE3	Adibendan Amrinone (inamrinone) Anagrelide Bucladesine Cilostamide Cilostazol Enoximone Imazodan KMUP-1 Meribendan Milrinone Olprinone Pimobendan Quazinone RPL-554 Siguazodan Tetomilast Tofimilast Trequinsin Vesnarinone

PDE4	AN2728 Apremilast Arofylline Atizoram Catramilast CC-1088 CDP-840 CGH-2466 Cilomilast Cipamfylline CP-80633 Crisaborole Denbutylline Drotaverine Etazolate Filaminast Glaucine HT-0712 ICI-63197 Indimilast Irsogladine Lavamilast Lirimilast Luteolin Mesembrenone Mesembrine Mesopram Oglemilast Piclamilast Revamilast Ro 20-1724 Roflumilast Rolipram Ronomilast RPL-554 RS-25344 YM-976

PDE5	Acetildenafil Aildenafil Avanafil Beminafil Benzamidenafil Dasantafil Icariin Gisadenafil Homosildenafil Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil

PDE7	BRL-50481

PDE9	BAY 73-6691 PF-04447943

PDE10	Papaverine PF-2545920 TC-E 5005 Tofisopam

PDE11	BC11-38

Nonselective	Aminophylline Caffeine Choline theophyllinate CPX Dipyridamole Doxofylline Enprofylline Ibudilast IBMX Luteolin Paraxanthine Pentoxifylline Propentofylline SCH-51866 Theobromine Theophylline Zaprinast Zardaverine

Unknown/unsorted	Benafentrine Carbazeran Diazepam Diphylline Doxofylline DPCPX Furafylline Lisofylline MDL-12330A Moxaverine Oxagrelate Parogrelil Pentifylline Proxyphylline Pumafentrine Quercetin Tolafentrine Trapidil

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