Bone morphogenetic protein 10

Bone morphogenetic protein 10
Identifiers
Symbols	BMP10 ; MGC126783
External IDs	OMIM: 608748 MGI: 1338820 HomoloGene: 7644 GeneCards: BMP10 Gene
Gene ontology Molecular function • cytokine activity • transforming growth factor beta receptor binding • hormone activity • protein binding • growth factor activity • telethonin binding • receptor serine/threonine kinase binding Cellular component • extracellular region • extracellular space • cytoplasm • cell surface • Z disc Biological process • cell adhesion • adult heart development • negative regulation of endothelial cell migration • positive regulation of cardiac muscle hypertrophy • negative regulation of cardiac muscle hypertrophy • positive regulation of pathway-restricted SMAD protein phosphorylation • extracellular matrix organization • negative regulation of cell growth • negative regulation of cell migration • BMP signaling pathway • activin receptor signaling pathway • regulation of apoptotic process • regulation of MAPK cascade • sarcomere organization • positive regulation of transcription, DNA-templated • cell development • atrial cardiac muscle tissue morphogenesis • ventricular cardiac muscle tissue morphogenesis • ventricular cardiac muscle cell development • regulation of cardiac muscle contraction • cardiac muscle cell proliferation • positive regulation of cardiac muscle cell proliferation • positive regulation of sarcomere organization • heart trabecula formation • pathway-restricted SMAD protein phosphorylation • SMAD protein signal transduction • positive regulation of cartilage development • regulation of cardiac muscle hypertrophy in response to stress • positive regulation of cell proliferation involved in heart morphogenesis Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	27302	12154
Ensembl	ENSG00000163217	ENSMUSG00000030046
UniProt	O95393	Q9R229
RefSeq (mRNA)	NM_014482	NM_009756
RefSeq (protein)	NP_055297	NP_033886
Location (UCSC)	Chr 2: 68.87 – 68.87 Mb	Chr 6: 87.43 – 87.43 Mb
PubMed search

Bone morphogenetic protein 10 (BMP10) is a protein that in humans is encoded by the BMP10 gene.^[1][2]

BMP10 is a polypeptide belonging to the TGF-β superfamily of proteins.^[2] It is a novel protein that, unlike most other BMP's, is likely to be involved in the trabeculation of the heart. Bone morphogenetic proteins are known for their ability to induce bone and cartilage development. BMP10 is categorized as a BMP since it shares a large sequence homology with other BMP's in the TGF-β superfamily.

Further reading

• Davila S, Froeling FE, Tan A, et al. (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
• Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
• Mazerbourg S, Sangkuhl K, Luo CW, et al. (2005). "Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses". J. Biol. Chem. 280 (37): 32122–32. doi:10.1074/jbc.M504629200. PMID 16049014.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Nakano N, Hori H, Abe M, et al. (2007). "Interaction of BMP10 with Tcap may modulate the course of hypertensive cardiac hypertrophy". Am. J. Physiol. Heart Circ. Physiol. 293 (6): H3396–403. doi:10.1152/ajpheart.00311.2007. PMID 17921333.
• Marroni F, Pfeufer A, Aulchenko YS, et al. (2009). "A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project". Circ Cardiovasc Genet 2 (4): 322–8. doi:10.1161/CIRCGENETICS.108.833806. PMC 2760953. PMID 20031603.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• David L, Mallet C, Mazerbourg S, et al. (2007). "Identification of BMP9 and BMP10 as functional activators of the orphan activin receptor-like kinase 1 (ALK1) in endothelial cells". Blood 109 (5): 1953–61. doi:10.1182/blood-2006-07-034124. PMID 17068149.

References

1. "Entrez Gene: bone morphogenetic protein 10".
2. Neuhaus H, Rosen V, Thies RS (February 1999). "Heart specific expression of mouse BMP-10 a novel member of the TGF-beta superfamily". Mech. Dev. 80 (2): 181–4. doi:10.1016/S0925-4773(98)00221-4. PMID 10072785.