SERPINA9
| Serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 9 | |||||||||||||
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| Identifiers | |||||||||||||
| Symbols | SERPINA9 ; GCET1; SERPINA11; SERPINA11b | ||||||||||||
| External IDs | OMIM: 615677 MGI: 1919157 HomoloGene: 23633 GeneCards: SERPINA9 Gene | ||||||||||||
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| Orthologs | |||||||||||||
| Species | Human | Mouse | |||||||||||
| Entrez | 327657 | 71907 | |||||||||||
| Ensembl | ENSG00000170054 | ENSMUSG00000058260 | |||||||||||
| UniProt | Q86WD7 | Q9D7D2 | |||||||||||
| RefSeq (mRNA) | NM_001042518 | NM_027997 | |||||||||||
| RefSeq (protein) | NP_001035983 | NP_082273 | |||||||||||
| Location (UCSC) |
Chr 14: 94.46 – 94.48 Mb |
Chr 12: 103.99 – 104.01 Mb | |||||||||||
| PubMed search | |||||||||||||
Serpin A9 also known as centerin or GCET1 is a protein that in humans is encoded by the SERPINA9 gene located on chromosome 14q32.1.[1] Serpin A9 is a member of the serpin family of serine protease inhibitors.
Function
The expression of SERPINA9 is restricted to germinal center B cells and lymphoid malignancies. SERPINA9 is likely to function in vivo in the germinal center as an efficient inhibitor of trypsin-like proteases.[2][3][4]
References
- ↑ "Entrez Gene: SERPINA9".
- ↑ Paterson MA, Horvath AJ, Pike RN, Coughlin PB (August 2007). "Molecular characterization of centerin, a germinal centre cell serpin". Biochem. J. 405 (3): 489–94. doi:10.1042/BJ20070174. PMC 2267310. PMID 17447896.
- ↑ Montes-Moreno S, Roncador G, Maestre L, Martínez N, Sanchez-Verde L, Camacho FI, Cannata J, Martinez-Torrecuadrada JL, Shen Y, Chan WC, Piris MA (January 2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas". Blood 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
- ↑ Paterson MA, Hosking PS, Coughlin PB (July 2008). "Expression of the serpin centerin defines a germinal center phenotype in B-cell lymphomas". Am. J. Clin. Pathol. 130 (1): 117–26. doi:10.1309/9QKE68QU7B825A3U. PMID 18550480.
Further reading
- Luke MM, O'Meara ES, Rowland CM, et al. (2009). "Gene variants associated with ischemic stroke: the cardiovascular health study.". Stroke 40 (2): 363–8. doi:10.1161/STROKEAHA.108.521328. PMC 2881155. PMID 19023099.
- Frazer JK, Jackson DG, Gaillard JP, et al. (2000). "Identification of centerin: a novel human germinal center B cell-restricted serpin.". Eur. J. Immunol. 30 (10): 3039–48. doi:10.1002/1521-4141(200010)30:10<3039::AID-IMMU3039>3.0.CO;2-H. PMID 11069088.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Morrison AC, Bare LA, Luke MM, et al. (2008). "Single nucleotide polymorphisms associated with coronary heart disease predict incident ischemic stroke in the atherosclerosis risk in communities study.". Cerebrovasc. Dis. 26 (4): 420–4. doi:10.1159/000155637. PMC 2662496. PMID 18799872.
- Shiffman D, O'Meara ES, Bare LA, et al. (2008). "Association of gene variants with incident myocardial infarction in the Cardiovascular Health Study.". Arterioscler. Thromb. Vasc. Biol. 28 (1): 173–9. doi:10.1161/ATVBAHA.107.153981. PMC 2636623. PMID 17975119.
- Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Montes-Moreno S, Roncador G, Maestre L, et al. (2008). "Gcet1 (centerin), a highly restricted marker for a subset of germinal center-derived lymphomas.". Blood 111 (1): 351–8. doi:10.1182/blood-2007-06-094151. PMID 17898315.
- Pan Z, Shen Y, Du C, et al. (2003). "Two newly characterized germinal center B-cell-associated genes, GCET1 and GCET2, have differential expression in normal and neoplastic B cells.". Am. J. Pathol. 163 (1): 135–44. doi:10.1016/S0002-9440(10)63637-1. PMC 1868163. PMID 12819018.
- Namciu SJ, Friedman RD, Marsden MD, et al. (2004). "Sequence organization and matrix attachment regions of the human serine protease inhibitor gene cluster at 14q32.1". Mamm. Genome 15 (3): 162–78. doi:10.1007/s00335-003-2311-y. PMID 15014966.
External links
- The MEROPS online database for peptidases and their inhibitors: I04.082
- SERPINA9 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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