Deoxyuridine phosphorylase

deoxyuridine phosphorylase
Identifiers
EC number	2.4.2.23
CAS number	37277-77-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

In enzymology, a deoxyuridine phosphorylase is an enzyme that catalyzes the chemical reaction

2'-deoxyuridine + phosphate $\rightleftharpoons$ uracil + 2-deoxy-alpha-D-ribose 1-phosphate

Thus, the two substrates of this enzyme are 2'-deoxyuridine and phosphate, whereas its two products are uracil and 2-deoxy-alpha-D-ribose 1-phosphate.

No enzyme is known to be specific for this reaction, hence the EC number originally assigned to this enzyme function (EC 2.4.2.23) was deleted by the IUBMB in 2013.^[1] The reaction is catalysed by EC 2.4.2.2, pyrimidine-nucleoside phosphorylase, EC 2.4.2.3, uridine phosphorylase, and EC 2.4.2.4, thymidine phosphorylase.

These enzymes belong to the family of glycosyltransferases, specifically the pentosyltransferases. They participate in pyrimidine metabolism.

References

1. "ExplorEnz: EC 2.4.2.23".

• Soukhova-O'Hare GK, Roberts AM, Gozal D (2006). "Impaired control of renal sympathetic nerve activity following neonatal intermittent hypoxia in rats". Neurosci. Lett. 399 (3): 181–5. doi:10.1016/j.neulet.2006.01.054. PMID 16495004.
• Yamada EW (1964). "The effect of cortisol administration on the activities of uridine and deoxyuridine phosphorylases of normal and regenerating rat liver". Can. J. Biochem. 42: 317–325.