Dihydroxy-acid dehydratase

dihydroxy-acid dehydratase
Identifiers
EC number 4.2.1.9
CAS number 9024-32-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dihydroxy-acid dehydratase (EC 4.2.1.9) is an enzyme that catalyzes the chemical reaction

2,3-dihydroxy-3-methylbutanoate \rightleftharpoons 3-methyl-2-oxobutanoate + H2O

Hence, this enzyme has one substrate, 2,3-dihydroxy-3-methylbutanoate, and two products, 3-methyl-2-oxobutanoate (α-ketoisovaleric acid) and H2O.

This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.

Nomenclature

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include

References

    Further reading

    • Kanamori M, Wixom RL (Mar 1963). "Studies in valine biosynthesis. V. Characteristics of the purified dihydroxyacid dehydratase from spinach leaves". The Journal of Biological Chemistry 238: 998–1005. PMID 13962154. 
    • Myers JW (May 1961). "Dihydroxy acid dehydrase: an enzyme involved in the biosynthesis of isoleucine and valine". The Journal of Biological Chemistry 236: 1414–8. PMID 13727223. 
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