Distigmine

Distigmine

Distigmine bromide
Systematic (IUPAC) name
(1-methylpyridin-1-ium-3-yl) N-methyl-N-{6-[methyl-
(1-methylpyridin-1-ium-3-yl)oxycarbonylamino]
hexyl}carbamate dibromide
Clinical data
Routes of
administration		 oral, i.m.
Pharmacokinetic data
Bioavailability 4.65 % [1]
Biological half-life 65 h [1]
Excretion renal [1]
Identifiers
CAS Number 15876-67-2
ATC code N07AA03 (WHO)
PubChem CID 27522
ChemSpider 25613 YesY
UNII T940307O7B YesY
KEGG D01228
ChEMBL CHEMBL1098285 YesY
Chemical data
Formula C22H32Br2N4O4
Molar mass 576.322 g/mol
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Distigmine (as distigmine bromide) is a parasympathomimetic. Distigmine is similar to pyridostigmine and neostigmine but has a longer duration of action. It is available as tablets on prescription only. Distigmine has a greater risk of causing cholinergic crisis because of accumulation of the drug being more likely than with neostigmine or pyridostigmine and so distigmine is rarely used as a treatment for myasthenia gravis, unlike pyridostigmine and neostigmine.

References

  1. 1 2 3 The Japanese Pharmacopoeia, Edition 14/I: Official Monographs, Yakuji Nippo. Ltd., Tokyo (2001), ISBN 978-4840806725, Page 599.


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